Shi Ya, Ye Luyao, Chen Qiuying, Hu Guangyi, Yin Yao, Fan Ying, Zhu Jianfeng, He Jiangnan, Zheng Zhi, Zou Haidong, Xu Xun
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
Front Med (Lausanne). 2021 Jun 8;8:648644. doi: 10.3389/fmed.2021.648644. eCollection 2021.
To characterize the longitudinal changes of macular vessel density in young adults and its associated factors. The right eyes of 309 participants (75 high myopic, 194 mild-to-moderate myopic, and 40 healthy) were followed up for 21 months. OCTA images were acquired at two visits using follow-up scans. Macular vessel density was calculated globally and in the nine early treatment diabetic retinopathy study (ETDRS) subfields of the macula superficial layer. The macular vessel density significantly decreased in young myopes after a 21-month follow up ( < 0.05), with variations among sectors. Compared with healthy eyes, HM group exhibited a faster reduction in global macular vessel density ( = 0.0307) as well as in sectors of inner-inferior (II), inner-temporal (IT), and outer-temporal (OT) (all < 0.05). Multivariate regression analysis showed that longer baseline axial length (AL) was significantly associated with larger reduction of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors (all < 0.05). Compared with emmetropes, high myopes presented greater loss of macular vessel density over time in global and in the inner-inferior, inner-temporal and outer-temporal sectors. A longer baseline AL was associated with larger changes of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors.
为了描述年轻成年人黄斑血管密度的纵向变化及其相关因素。对309名参与者（75名高度近视、194名轻度至中度近视和40名健康者）的右眼进行了21个月的随访。使用随访扫描在两次就诊时采集光学相干断层扫描血管造影（OCTA）图像。计算黄斑整体以及黄斑表层九个早期糖尿病视网膜病变研究（ETDRS）子区域的血管密度。21个月随访后，年轻近视者的黄斑血管密度显著降低（<0.05），各区域存在差异。与健康眼相比，高度近视组黄斑整体血管密度（=0.0307）以及内下（II）、颞内（IT）和颞外（OT）区域的血管密度下降更快（均<0.05）。多因素回归分析显示，较长的基线眼轴长度（AL）与内下、颞内和颞外区域黄斑血管密度的更大降低显著相关（均<0.05）。与正视眼相比，高度近视者在整体以及内下、颞内和颞外区域随时间黄斑血管密度损失更大。较长的基线AL与内下、颞内和颞外区域黄斑血管密度的更大变化相关。
