Patel Seema
Bioinformatics and Medical Informatics Research Center, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182, USA.
Biomed Pharmacother. 2017 Jul;91:767-775. doi: 10.1016/j.biopha.2017.05.010. Epub 2017 May 10.
Homeostasis of immune-endocrine-neural axis is paramount for human health. If this axis gets agitated due to age, genetic variations, environmental exposures or lifestyle assaults, a cascade of adverse reactions occurs in human body. Cytokines, hormones and neurotransmitters, the effector molecules of this axis behave erratically, leading to a gamut of neural, endocrine, autoimmune, and metabolic diseases. Current panel of drugs can tackle some of them but not in a sustainable, benign way as a myriad of side effects, causal of them have been documented. In this context, phytochemicals, the secondary metabolites of plants seem beneficial. These bioactive constituents encompassing polyphenols, alkaloids, flavonoids, terpenoids, tannins, lignans, stilbenoids (resveratrol), saponins, polysaccharides, glycosides, and lectins etc. have been proven to exert antioxidant, anti-inflammatory, hypolipidemic, hypotensive, antidiabetic, anticancer, immunomodulatory, anti-allergic, analgesic, hepatoprotective, neuroprotective, dermatoprotective, and antimicrobial properties, among a litany of other biological effects. This review presents a holistic perspective of common afflictions resultant of immune-endocrine-neural axis disruption, and the phytochemicals capable of restoring their normalcy and mitigating the ailments.
免疫 - 内分泌 - 神经轴的稳态对人类健康至关重要。如果该轴因年龄、基因变异、环境暴露或生活方式的影响而受到干扰，人体就会发生一系列不良反应。细胞因子、激素和神经递质作为该轴的效应分子，其行为变得不稳定，从而导致一系列神经、内分泌、自身免疫和代谢疾病。目前的药物组合可以治疗其中一些疾病，但并非以可持续、良性的方式进行，因为已记录了众多与之相关的副作用。在这种情况下，植物化学物质，即植物的次生代谢产物似乎有益。这些生物活性成分包括多酚、生物碱、黄酮类化合物、萜类化合物、单宁、木脂素、芪类化合物（白藜芦醇）、皂苷、多糖、糖苷和凝集素等，已被证明具有抗氧化、抗炎、降血脂、降血压、抗糖尿病、抗癌、免疫调节、抗过敏、镇痛、保肝、神经保护、皮肤保护和抗菌等特性，以及许多其他生物学效应。本综述全面阐述了免疫 - 内分泌 - 神经轴紊乱导致的常见疾病，以及能够恢复其正常状态并减轻疾病的植物化学物质。
