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根部乙醇提取物对人皮肤成纤维细胞的抗光老化作用

Anti-Photoaging Effects of Root Ethanol Extract in Human Dermal Fibroblasts.

作者信息

Park Min Ah, Sim Mi Ja, Kim Young Chul

机构信息

In Vitro Evaluation Team, Ellead Sin & Bio Research, Osong, Korea.

Department of Health & Beauty Science, Gyeongbuk Provincial College, Yecheon, Korea.

出版信息

Toxicol Res. 2017 Apr;33(2):125-134. doi: 10.5487/TR.2017.33.2.125. Epub 2017 Apr 15.

DOI:10.5487/TR.2017.33.2.125
PMID:28503261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5426508/
Abstract

The effects that ultraviolet rays elicit on collagen synthesis and degradation are the most common causes of wrinkle formation and photo-aging in skin. The objectives of this study were to evaluate the effects of root ethanol extract (AAEE) to promote collagen synthesis and inhibit collagen degradation in human dermal fibroblasts. By examining total polyphenol and flavonoid contents, electron donating ability, radical scavenging activity, and superoxide dismutase-like activity, we found that AAEE exhibited fairly good antioxidant activity. Treatment with AAEE significantly increased type I procollagen production by cultured fibroblasts, as well as reduced ultraviolet-induced matrix metalloproteinase-1 (MMP-1) expression and MMP-2 activity in a dose-dependent manner ( < 0.05). In addition, AAEE significantly increased TIMP-1 mRNA expression ( < 0.05), although without an associated dose-dependent increase in TIMP-1 protein expression. In summary, we suggest that AAEE may be a potentially effective agent for the prevention or alleviation of skin-wrinkle formation induced by ultraviolet rays.

摘要

紫外线对胶原蛋白合成和降解产生的影响是皮肤皱纹形成和光老化最常见的原因。本研究的目的是评估根乙醇提取物（AAEE）对促进人皮肤成纤维细胞胶原蛋白合成及抑制胶原蛋白降解的作用。通过检测总多酚和类黄酮含量、电子供体能力、自由基清除活性和超氧化物歧化酶样活性，我们发现AAEE表现出相当良好的抗氧化活性。用AAEE处理可显著增加培养的成纤维细胞中I型前胶原的产生，并以剂量依赖方式降低紫外线诱导的基质金属蛋白酶-1（MMP-1）表达和MMP-2活性（P<0.05）。此外，AAEE显著增加TIMP-1 mRNA表达（P<0.05），尽管TIMP-1蛋白表达没有相应的剂量依赖性增加。总之，我们认为AAEE可能是预防或减轻紫外线诱导的皮肤皱纹形成的潜在有效药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/378c4355d8bf/tr-33-125f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/65e5a79256df/tr-33-125f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/9f44fc21c298/tr-33-125f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/fb1aff5b005f/tr-33-125f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/d63a55ab9fe0/tr-33-125f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/dd56abe32672/tr-33-125f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/d081bd33e649/tr-33-125f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/378c4355d8bf/tr-33-125f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/65e5a79256df/tr-33-125f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/9f44fc21c298/tr-33-125f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/fb1aff5b005f/tr-33-125f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/d63a55ab9fe0/tr-33-125f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/dd56abe32672/tr-33-125f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/d081bd33e649/tr-33-125f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2195/5426508/378c4355d8bf/tr-33-125f7.jpg

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