阿萨伊浆果水提取物对皮肤伤口的愈合作用及作用机制
Skin Wound Healing Effects and Action Mechanism of Acai Berry Water Extracts.
作者信息
Kang Mi Hyun, Choi Seunghye, Kim Bae-Hwan
机构信息
Major in Public Health, Faculty of Food and Health Sciences, Keimyung University, Daegu, Korea.
College of Pharmacy, Ewha Womans University, Seoul, Korea.
出版信息
Toxicol Res. 2017 Apr;33(2):149-156. doi: 10.5487/TR.2017.33.2.149. Epub 2017 Apr 15.
The purpose of this study was to investigate the wound healing effect of acai berry water extracts (ABWE) and a possible underlying mechanism involved in its action using various and models. The wound healing effect of ABWE was evaluated by migration assay using HS68 fibroblast cells. In addition, its effect on mRNA expression of procollagen, fibronectin, and MMP-1 was determined. Moreover, the wound healing effect of ABWE was evaluated in wound models through macroscopic and microscopic observation. In addition, mRNA expression levels of wound related genes were determined. Results revealed that ABWE was not cytotoxic. It increased migration of HS68 fibroblast cells. ABWE increased mRNA expression levels of fibronectin but decreased the mRNA expression levels of MMP-1. ABWE also showed significantly potent wound healing effect based on macroscopic and histopathological observation and mRNA expression evaluation for wound related genes. Taken together, our results indicated that ABWE might have potential as a wound healing agent.
本研究的目的是使用各种细胞和动物模型，研究阿萨伊浆果水提取物（ABWE）的伤口愈合效果及其作用可能的潜在机制。通过使用HS68成纤维细胞的迁移试验评估ABWE的伤口愈合效果。此外，还测定了其对前胶原、纤连蛋白和基质金属蛋白酶-1（MMP-1）mRNA表达的影响。此外，通过宏观和微观观察在动物伤口模型中评估ABWE的伤口愈合效果。此外，还测定了伤口相关基因的mRNA表达水平。结果显示ABWE没有细胞毒性。它增加了HS68成纤维细胞的迁移。ABWE增加了纤连蛋白的mRNA表达水平，但降低了MMP-1的mRNA表达水平。基于宏观和组织病理学观察以及伤口相关基因的mRNA表达评估，ABWE还显示出显著有效的伤口愈合效果。综上所述，我们的结果表明ABWE可能具有作为伤口愈合剂的潜力。
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