Qiao Yuan, Li Qiang, Du Hong-Yang, Wang Qiao-Wei, Huang Ye, Liu Wei
Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China; Department of Dermatology, The Air Force General Hospital of PLA, Beijing, 100142, China.
Department of Dermatology, The Air Force General Hospital of PLA, Beijing, 100142, China.
Biochem Biophys Res Commun. 2017 Jul 1;488(3):445-452. doi: 10.1016/j.bbrc.2017.04.160. Epub 2017 May 17.
Accumulating evidence suggests that polycyclic aromatic hydrocarbons (PAH) which adsorbed on the surface of ambient air particulate matters (PM), are the major toxic compound to cause cardiovascular and respiratory diseases, even cancer. However, its detrimental effects on human skin cell remain unclear. Here, we demonstrated that SRM1649b, a reference urban dust material of PAH, triggers human skin cells aging through cell cycle arrest, cell growth inhibition and apoptosis. Principally, SRM1649b facilitated Aryl hydrocarbon receptor (AhR) translocated into nucleus, subsequently activated ERK/MAPK signaling pathway, and upregulated aging-related genes expression. Most important, we found that AhR antagonist efficiently revert the aging of skin cells. Thus our novel findings firstly revealed the mechanism of skin aging under PAH contamination and provided potential strategy for clinical application.
越来越多的证据表明，吸附在环境空气颗粒物（PM）表面的多环芳烃（PAH）是导致心血管和呼吸系统疾病甚至癌症的主要有毒化合物。然而，其对人类皮肤细胞的有害影响仍不清楚。在此，我们证明了PAH的参考城市灰尘物质SRM1649b通过细胞周期停滞、细胞生长抑制和凋亡引发人类皮肤细胞衰老。主要地，SRM1649b促进芳烃受体（AhR）转运到细胞核，随后激活ERK/MAPK信号通路，并上调衰老相关基因的表达。最重要的是，我们发现AhR拮抗剂能有效逆转皮肤细胞的衰老。因此，我们的新发现首次揭示了PAH污染下皮肤衰老的机制，并为临床应用提供了潜在策略。
