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外泌体在癌症治疗与诊断中的新兴应用。

Emerging applications of exosomes in cancer therapeutics and diagnostics.

作者信息

Inamdar Sahil, Nitiyanandan Rajeshwar, Rege Kaushal

机构信息

Chemical Engineering Arizona State University Tempe AZ 85287.

Biological Design Program, Arizona State University Tempe AZ 85287.

出版信息

Bioeng Transl Med. 2017 Mar;2(1):70-80. doi: 10.1002/btm2.10059. Epub 2017 Apr 3.

DOI:10.1002/btm2.10059
PMID:28529978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5413841/
Abstract

Exosomes are nanoscale extracellular vesicles that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communication. These vesicles can be isolated from different body fluids and their small sizes make them attractive in various biomedical applications. Here, we review state-of-the art approaches in exosome isolation and purification, and describe their potential use in cancer vaccines, drug delivery, and diagnostics.

摘要

外泌体是纳米级的细胞外囊泡，由体内不同细胞释放。外泌体包裹着多种生物分子，包括脂质、蛋白质和核酸，因此在细胞通讯中可发挥关键作用。这些囊泡可从不同体液中分离出来，其小尺寸使其在各种生物医学应用中具有吸引力。在此，我们综述外泌体分离和纯化的最新方法，并描述它们在癌症疫苗、药物递送和诊断中的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/55466fc1f565/BTM2-2-070-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/e853d8f6f468/BTM2-2-070-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/78648b6856d1/BTM2-2-070-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/19c2f6868ae3/BTM2-2-070-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/6f33c36c813f/BTM2-2-070-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/f38076ce2342/BTM2-2-070-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/bf9c603bfb34/BTM2-2-070-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/55466fc1f565/BTM2-2-070-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/e853d8f6f468/BTM2-2-070-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/78648b6856d1/BTM2-2-070-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/19c2f6868ae3/BTM2-2-070-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/6f33c36c813f/BTM2-2-070-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/f38076ce2342/BTM2-2-070-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/bf9c603bfb34/BTM2-2-070-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f933/5689525/55466fc1f565/BTM2-2-070-g007.jpg

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Curr Protoc Immunol. 2016 Nov 1;115:14.42.1-14.42.21. doi: 10.1002/cpim.17.
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Tumor-Derived Exosomes and Their Role in Tumor-Induced Immune Suppression.
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