Department of Mechanical Engineering, McGill University, Montreal, Quebec H3A 0C3, Canada.
Nanoscale. 2017 Jun 8;9(22):7320-7341. doi: 10.1039/c7nr01577a.
Biosensing has found wide applications in biological and medical research, and in clinical diagnosis, environmental monitoring and other analytical tasks. Recognized as novel and outstanding transducing materials because of their superior and unique physical/chemical properties, group III nitride (III-nitride) nanomaterials have been introduced into biosensor development with remarkable advancements achieved in the past few decades. This paper presents the first comprehensive review on biosensor development with III-nitride nanomaterials. The review starts with the introduction of the material properties and biocompatibility of III-nitrides that are useful for biosensing. The focus is then placed on surface treatments of III-nitrides, which lay the foundation for biosensing, and on biosensing mechanisms where the exceptional properties of III-nitride nanomaterials lead to superior biosensing performance. From a practical point of view, techniques for biosensor fabrication are then summarized. Finally, existing biosensing applications and future directions are discussed.
生物传感在生物和医学研究以及临床诊断、环境监测和其他分析任务中得到了广泛的应用。由于其优越和独特的物理/化学性质，III 族氮化物（III-nitride）纳米材料被认为是新型的出色的转换材料，在过去几十年中，它们在生物传感器的发展中得到了引人注目的进展。本文对基于 III-nitride 纳米材料的生物传感器发展进行了全面综述。综述首先介绍了 III-nitrides 的材料特性和生物相容性，这些特性对生物传感很有用。然后重点介绍了 III-nitrides 的表面处理，这为生物传感奠定了基础，以及生物传感机制，其中 III-nitride 纳米材料的特殊性质导致了优越的生物传感性能。从实际的角度来看，然后总结了生物传感器制造的技术。最后，讨论了现有的生物传感应用和未来的方向。
