a School of Medicine, Department of Ophthalmology , Koc University , Istanbul , Turkey.
b Department of Ophthalmology , V.K. Foundation, American Hospital , Istanbul , Turkey.
Ocul Immunol Inflamm. 2018;26(7):1078-1093. doi: 10.1080/09273948.2017.1319959. Epub 2017 May 26.
To screen for psychological disorders in patients with active uveitis.
Patients were screened for depression (BDI-II), state anxiety (STAI-I), VR-QOL (NEI-VFQ-25), and HR-QOL (SF-36). Association of depression and anxiety with sociodemographic and clinical parameters and with VR-QOL and HR-QOL were analyzed. Multivariate linear regression models were constructed for NEI-VFQ-25 and SF-36 subscales.
Of 99 patients, 37.3% screened positive for depression and 52.5% for anxiety. Depressed patients had lower visual acuity in the better seeing eye (p = 0.013) and more frequently panuveitis (p = 0.018). Anxious patients were younger (p = 0.009), had earlier onset of uveitis (p = 0.015), and had more frequently panuveitis (p = 0.016). Bivariate comparisons showed significant associations between psychological disorders and VR-QOL and HR-QOL. Significant bivariate associations were mostly lost in multivariate analyses for anxiety, but were preserved for depression.
A positive screening test for depression and anxiety is common in patients with uveitis. Low vision and panuveitis are associated with depression. Depression is associated with impairment of VR-QOL and HR-QOL.
筛选活动性葡萄膜炎患者的心理障碍。
对患者进行抑郁（BDI-II）、状态焦虑（STAI-I）、VR-QOL（NEI-VFQ-25）和 HR-QOL（SF-36）的筛查。分析抑郁和焦虑与社会人口统计学和临床参数以及与 VR-QOL 和 HR-QOL 的相关性。为 NEI-VFQ-25 和 SF-36 子量表构建多元线性回归模型。
99 例患者中，37.3%筛查出抑郁，52.5%筛查出焦虑。抑郁患者的较佳眼视力（p = 0.013）和更频繁的全葡萄膜炎（p = 0.018）较低。焦虑患者更年轻（p = 0.009），葡萄膜炎发病更早（p = 0.015），更频繁地发生全葡萄膜炎（p = 0.016）。在单变量比较中，心理障碍与 VR-QOL 和 HR-QOL 之间存在显著相关性。在多变量分析中，焦虑的显著相关性大多丧失，但抑郁仍存在。
葡萄膜炎患者的抑郁和焦虑筛查呈阳性。视力低下和全葡萄膜炎与抑郁有关。抑郁与 VR-QOL 和 HR-QOL 受损有关。
