Department of Ophthalmology and Visual Science, Eye, Ear, Nose, and Throat Hospital, Shanghai Medical College of Fudan University.
Key Laboratory of Myopia, Ministry of Health.
J Glaucoma. 2019 Mar;28(3):207-215. doi: 10.1097/IJG.0000000000001178.
The purpose of this study was to assess the vision-related quality of life (VR-QoL) in glaucoma patients and its correlations with psychological disturbances and visual function components.
The 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) and Hospital Anxiety and Depression Scale (HADS) questionnaires were administered to 428 Chinese glaucoma patients to evaluate their VR-QoL and anxiety and depression disorders, respectively. Sociodemographical and clinical factors were collected at the same time. Univariate analyses were used to investigate the associations between the variables and the VR-QoL. Multivariate linear regression analyses were used to identify the independent psychological and visual functional predictors of the VR-QoL. Standardized partial regression analyses were used to reveal the variables that mostly relevant to the VR-QoL.
The composite score (mean±SD) was 71.88±14.44 for NEI VFQ-25 and 13.17±6.56 for HADS. Visual function indices, including best-corrected visual acuity and mean deviation of both eyes in addition to psychological symptoms including anxiety and depression were both correlated with VR-QoL significantly, even after adjusting for sociodemographical and clinical factors. Standardized partial regression analyses further suggested that psychological disorders, especially anxiety rather than visual function components, were mostly relevant to VR-QoL.
Deterioration of vision impairment and visual field defects in addition to increased recognition of psychological disturbances reduce the VR-QoL of glaucoma patients significantly. Alleviating psychological symptoms, especially anxiety, perhaps have a greater influence on the improvement of VR-QoL.
本研究旨在评估青光眼患者的视觉相关生活质量（VR-QoL）及其与心理障碍和视觉功能成分的相关性。
对 428 名中国青光眼患者进行了 25 项国家眼科研究所视觉功能问卷（NEI VFQ-25）和医院焦虑抑郁量表（HADS）问卷调查，以评估他们的 VR-QoL 以及焦虑和抑郁障碍。同时收集社会人口统计学和临床因素。使用单变量分析来研究变量与 VR-QoL 之间的关联。使用多元线性回归分析来确定 VR-QoL 的独立心理和视觉功能预测因子。使用标准化偏回归分析来揭示与 VR-QoL 最相关的变量。
NEI VFQ-25 的综合评分（均值±标准差）为 71.88±14.44，HADS 为 13.17±6.56。视觉功能指标，包括最佳矫正视力和双眼平均偏差，以及包括焦虑和抑郁在内的心理症状，与 VR-QoL 显著相关，即使在调整了社会人口统计学和临床因素后也是如此。标准化偏回归分析进一步表明，心理障碍，尤其是焦虑，而不是视觉功能成分，与 VR-QoL 最相关。
视力损害和视野缺陷的恶化以及对心理障碍的认识增加，显著降低了青光眼患者的 VR-QoL。缓解心理症状，特别是焦虑，可能对改善 VR-QoL 有更大的影响。
