Osama Hasnaa, Abdullah Aya, Gamal Bassma, Emad Dina, Sayed Doha, Hussein Eman, Mahfouz Eman, Tharwat Joy, Sayed Sally, Medhat Shrouk, Bahaa Treza, Abdelrahim Mohamed E A
a Faculty of Pharmacy , Beni-suef University , Beni-suef , Egypt.
b Faculty of Pharmacy , Ahram Canadian University , Giza , Egypt.
J Am Coll Nutr. 2017 Jul;36(5):342-346. doi: 10.1080/07315724.2017.1292157. Epub 2017 May 26.
Cisplatin constitutes one of the most potent antineoplastic drugs; however, nephrotoxicity limited its eligibility for optimal clinical use. This study was designed to evaluate the role of honey and royal jelly with antioxidant properties in the protection of cisplatin-induced acute kidney injury in patients with cancer.
Patients with cancer assigned for cisplatin chemotherapy were randomly divided into bee honey and royal jelly groups pretreated before the initiation and during cisplatin chemotherapeutic regimen and control group on cisplatin only. Serum creatinine and urea levels were measured before and after the chemotherapeutic cycle and over 2 cycles.
Patients on crude bee honey and royal jelly capsules showed lower serum levels of renal injury products (creatinine and urea) compared to those in the control group. The changes in kidney parameters were significantly (p < 0.05) lower when compared within the bee honey group before and after cisplatin treatment. Royal jelly was found to be effective; however, the difference in creatinine and urea levels before and after chemotherapy was not statistically significant.
The use of bee honey and royal jelly as natural compounds is effective in reducing cisplatin nephrotoxicity and may offer a promising chance for clinically meaningful prevention. This study has potentially important implications for the treatment of cisplatin kidney side effects and is considered to be the first to investigate this effect of honey and royal jelly in human subjects. However, due to its small sample size, we recommend further investigation using a larger sample size.
顺铂是最有效的抗肿瘤药物之一；然而，肾毒性限制了其在最佳临床应用中的适用性。本研究旨在评估具有抗氧化特性的蜂蜜和蜂王浆在保护癌症患者顺铂诱导的急性肾损伤中的作用。
被指定接受顺铂化疗的癌症患者被随机分为蜂蜜组和蜂王浆组，在顺铂化疗方案开始前及期间进行预处理，以及仅接受顺铂治疗的对照组。在化疗周期前后及两个周期内测量血清肌酐和尿素水平。
与对照组相比，服用粗制蜂蜜和蜂王浆胶囊的患者血清肾损伤产物（肌酐和尿素）水平较低。与顺铂治疗前后的蜂蜜组相比，肾脏参数的变化显著更低（p < 0.05）。发现蜂王浆有效；然而，化疗前后肌酐和尿素水平的差异无统计学意义。
使用蜂蜜和蜂王浆作为天然化合物可有效降低顺铂肾毒性，并可能为具有临床意义的预防提供一个有前景的机会。本研究对顺铂肾脏副作用的治疗具有潜在重要意义，并且被认为是首个在人体中研究蜂蜜和蜂王浆这种作用的研究。然而，由于样本量小，我们建议使用更大样本量进行进一步研究。
