Nguyen Hien Minh, Ito Takuya, Kurimoto Shin-Ichiro, Ogawa Mika, Win Nwet Nwet, Hung Vo Quoc, Nguyen Hoai Thi, Kubota Takaaki, Kobayashi Jun'ichi, Morita Hiroyuki
Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Bioorg Med Chem Lett. 2017 Jul 15;27(14):3043-3047. doi: 10.1016/j.bmcl.2017.05.060. Epub 2017 May 19.
The investigation of the Vietnamese marine sponge Spongia sp. led to the isolation of three new sesquiterpene phenols, langconols A-C (1-3), and one new sesquiterpene hydroxyquinone, langcoquinone C (4), together with two known meroterpenoids (5 and 6). Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. Furthermore, the antibacterial assays of the isolates 1-6 suggested that 4 and 6 had significant antibacterial activities against Bacillus subtilis and Staphylococcus aureus, with MICs ranging from 6.25 to 25.0µM, while 1 and 3 possessed significant antibacterial activities against B. subtilis with MICs of 12.5 and 25.0µM, respectively. In contrast, cytotoxic assays of the isolated compounds 1-6, as well as compounds 7-15 previously isolated from this sponge, indicated that 1 and the previously reported anti-B. subtilis and anti-S. aureus sesquiterpene phenol 9 lacked cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervix cancer) and a human normal cell line (WI-38 fibroblast).
对越南海洋海绵Spongia sp. 的研究导致分离出三种新的倍半萜酚类化合物，即朗康醇A - C（1 - 3），以及一种新的倍半萜羟基醌，即朗醌C（4），同时还分离出两种已知的半萜类化合物（5和6）。它们的结构是基于光谱分析并与已发表的数据进行比较而确定的。此外，对分离物1 - 6的抗菌试验表明，4和6对枯草芽孢杆菌和金黄色葡萄球菌具有显著的抗菌活性，其最低抑菌浓度（MIC）范围为6.25至25.0μM，而1和3对枯草芽孢杆菌具有显著的抗菌活性，其MIC分别为12.5和25.0μM。相比之下，对分离出的化合物1 - 6以及先前从该海绵中分离出的化合物7 - 15的细胞毒性试验表明，1以及先前报道的抗枯草芽孢杆菌和抗金黄色葡萄球菌的倍半萜酚9对三种人类癌细胞系（A549，肺癌；MCF7，乳腺癌；HeLa，宫颈癌）和一种人类正常细胞系（WI - 38成纤维细胞）缺乏细胞毒性活性。
