Taheri Shahram, Baradaran Azar, Aliakbarian Mahnaz, Mortazavi Mojgan
Department of Internal Medicine, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2017 Apr 26;22:47. doi: 10.4103/jrms.JRMS_282_15. eCollection 2017.
Considering the existence of controversies about the predictive value of inflammatory markers for cardiovascular disease (CVD), we aimed to compare the level of high-sensitivity C-reactive protein (hs-CRP) and interlukin-6 (IL-6) level in chronic hemodialysis (HD) patients with and without CVD.
In this historical cohort study, HD patients with and without CVD disease were enrolled. The presence of CVD risk factors, level of inflammatory factors including IL-6 and hs-CRP as well as lipid levels, fasting blood sugar, and other biochemical factors were compared in two studied groups.
During the study, eighty HD patients with ( = 40) and without ( = 40) CVD were enrolled. Diabetes was more prevalent among HD patients with CVD than those without CVD ( < 0.05). The level of IL-6 and hs-CRP were not different in two studied groups ( > 0.05). Univariate analysis of variance test indicated that there was not any significant relationship between hs-CRP and CVD ( > 0.05).
The findings indicated that the level of inflammatory factors including hs-CRP and IL-6 are not significantly different in HD patients with and without CVD. However, for obtaining more definite conclusion in this field and evaluation their predicting role in this field, it is recommended to study other novel inflammatory markers as well as the additive effect of the inflammatory factors with traditional ones in larger sample size and longer follow-up.
鉴于炎症标志物对心血管疾病（CVD）预测价值存在争议，我们旨在比较有和没有CVD的慢性血液透析（HD）患者的高敏C反应蛋白（hs-CRP）水平和白细胞介素-6（IL-6）水平。
在这项历史性队列研究中，纳入了有和没有CVD疾病的HD患者。比较了两个研究组中CVD危险因素的存在情况、包括IL-6和hs-CRP在内的炎症因子水平以及血脂水平、空腹血糖和其他生化因子。
在研究期间，纳入了80例HD患者，其中有CVD的40例，无CVD的40例。患有CVD的HD患者中糖尿病比没有CVD的患者更普遍（P<0.05）。两个研究组中IL-6和hs-CRP水平没有差异（P>0.05）。单因素方差分析表明hs-CRP与CVD之间没有任何显著关系（P>0.05）。
研究结果表明，有和没有CVD的HD患者中包括hs-CRP和IL-6在内的炎症因子水平没有显著差异。然而，为了在该领域获得更明确的结论并评估它们在该领域的预测作用，建议在更大样本量和更长随访时间内研究其他新型炎症标志物以及炎症因子与传统标志物的相加作用。
