Mantovani Alessandro, Perrone Fabrizia, Stoico Vincenzo, Pichiri Isabella, Salvotelli Laura, Teobaldi Ilaria, Bruti Massimiliano, Conti Michela, Cima Luca, Eccher Albino, Bonora Enzo
Division of EndocrinologyDiabetes and Metabolism, Department of Medicine.
Division of Plastic SurgeryDepartment of Surgery.
Endocrinol Diabetes Metab Case Rep. 2017 May 24;2017. doi: 10.1530/EDM-17-0032. eCollection 2017.
The incidences of type 2 diabetes mellitus and many cancers are rapidly increasing worldwide. Diabetes is a strong risk factor for some cancers (including lymphomas) and is also associated with adverse cancer outcomes. After gastrointestinal tract, the skin is the second most frequent extranodal site involved by non-Hodgkin lymphomas and the cutaneous B-cell lymphomas (CBCLs) range from 25% to 30% of all primary cutaneous lymphomas. The primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) is an aggressive lymphoma with a poor prognosis, representing roughly 20% of all primary CBCLs. Classically, the cutaneous manifestation of this lymphoma is a red or violaceous tumors arising on a leg. To date, despite the large body of evidence suggesting that diabetes is strongly associated with an increased risk of some cancers, very little information is available regarding a possible association between type 2 diabetes and primary cutaneous diffuse large B-cell lymphoma. In this report, we will present the case of a white adult patient with type 2 diabetes with chronic leg ulcers complicated by a primary cutaneous diffuse large B-cell lymphoma.
Diabetes mellitus is increasing worldwide as well as the incidence of many cancers.Diabetes mellitus is a powerful risk factor for some cancers (including lymphomas) and is strongly associated with adverse cancer outcomes.Seen that diabetes is strongly associated with an increased risk of cancers (including cutaneous lymphomas), clinicians should always keep in mind this complication in elderly patients with type 2 diabetes, even in a chronic leg ulcer with hypertrophy of the wound edge, which is hard to heal and does not have the typical characteristics of a diabetic or vascular ulcer. In these cases, a biopsy should be performed to rule out a neoplasm.Early diagnosis and correct management of cancer in a patient with type 2 diabetes are crucial to improve clinical outcomes.
2型糖尿病和多种癌症的发病率在全球范围内正在迅速上升。糖尿病是某些癌症（包括淋巴瘤）的重要危险因素，并且还与不良的癌症预后相关。在胃肠道之后，皮肤是结外非霍奇金淋巴瘤最常累及的第二个部位，皮肤B细胞淋巴瘤（CBCL）占所有原发性皮肤淋巴瘤的25%至30%。原发性皮肤弥漫性大B细胞淋巴瘤（PCDLBCL）是一种侵袭性淋巴瘤，预后较差，约占所有原发性CBCL的20%。传统上，这种淋巴瘤的皮肤表现为腿部出现的红色或紫色肿瘤。迄今为止，尽管大量证据表明糖尿病与某些癌症风险增加密切相关，但关于2型糖尿病与原发性皮肤弥漫性大B细胞淋巴瘤之间可能存在的关联的信息却非常少。在本报告中，我们将介绍一例患有2型糖尿病的白人成年患者，其慢性腿部溃疡并发原发性皮肤弥漫性大B细胞淋巴瘤的病例。
糖尿病在全球范围内以及许多癌症的发病率都在上升。糖尿病是某些癌症（包括淋巴瘤）的强大危险因素，并且与不良的癌症预后密切相关。鉴于糖尿病与癌症（包括皮肤淋巴瘤）风险增加密切相关，临床医生应始终牢记2型糖尿病老年患者的这种并发症，即使是在伤口边缘肥厚、难以愈合且不具有典型糖尿病或血管性溃疡特征的慢性腿部溃疡患者中。在这些情况下，应进行活检以排除肿瘤。对2型糖尿病患者的癌症进行早期诊断和正确管理对于改善临床结局至关重要。
