Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Semin Cell Dev Biol. 2017 Sep;69:18-25. doi: 10.1016/j.semcdb.2017.05.018. Epub 2017 May 31.
At the surface of the body, the epidermis covers great depth in its developmental regulation. While many genes have been shown to be important for skin development through their associations with disease phenotypes in mice and human, it is in the past decade that the intricate interplay between various molecules become gradually revealed through sophisticated genetic models and imaging analyses. In particular, there is increasing evidence suggesting that cytoskeleton-associated proteins, including adhesion proteins and the crosslinker proteins may play critical roles in regulating epidermis development. We here provide a broad overview of the various molecules involved in epidermal development with special emphasis on the cytoskeletal components.
在体表，表皮在其发育调控中覆盖着很大的深度。虽然许多基因已经通过与小鼠和人类的疾病表型的关联被证明对皮肤发育很重要，但直到过去十年，通过复杂的遗传模型和成像分析，各种分子之间的复杂相互作用才逐渐被揭示出来。特别是，越来越多的证据表明，细胞骨架相关蛋白，包括黏附蛋白和交联蛋白，可能在调节表皮发育中发挥关键作用。我们在这里提供了一个广泛的表皮发育过程中涉及的各种分子的概述，特别强调了细胞骨架成分。
