[C] 芳基硼酸在水溶液中的氰化反应。
[C]Cyanation of arylboronic acids in aqueous solutions.
作者信息
Ma Longle, Placzek Michael S, Hooker Jacob M, Vasdev Neil, Liang Steven H
机构信息
Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Chem Commun (Camb). 2017 Jun 21;53(49):6597-6600. doi: 10.1039/c7cc02886e. Epub 2017 Jun 5.
Abstract
A copper-mediated C-cyanation method employing arylboronic acids and [C]HCN has been developed. This method was applied to the radiochemical synthesis of a wide range of aromatic C-nitriles in aqueous solutions. The use of readily accessible arylboronic acids as precursors makes this method complementary to the well-established C-cyanation methods that utilize aryl halide precursors.
摘要
已开发出一种使用芳基硼酸和[C]HCN的铜介导的C-氰化方法。该方法应用于水溶液中多种芳香族C-腈的放射化学合成。使用易于获得的芳基硼酸作为前体，使得该方法与利用芳基卤化物前体的成熟C-氰化方法互为补充。
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