Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Department of Statistics.
Bioinformatics. 2017 Dec 1;33(23):3793-3795. doi: 10.1093/bioinformatics/btx359.
MOTIVATION: High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability. RESULTS: We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTL results and functional genomics data. AVAILABILITY AND IMPLEMENTATION: HUGIn is available at http://yunliweb.its.unc.edu/HUGIn. CONTACT: yunli@med.unc.edu or hum@ccf.org. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
动机：高通量染色质构象捕获（3C）技术，如 Hi-C 和 ChIA-PET，具有阐明非编码变异体功能作用的潜力。然而，大多数已发表的全基因组无偏染色质组织研究都使用了培养的细胞系，限制了它们的通用性。
结果：我们开发了一个网络浏览器 HUGIn，用于可视化从 21 个人体组织和细胞系中生成的 Hi-C 数据。HUGIn 能够评估任何基因组位置的染色质接触，包括 GWAS SNPs、eQTL 和顺式调控元件，既可以评估组织特异性和细胞系特异性的染色质接触，也可以评估全基因组关联研究（GWAS）和表达数量性状基因座（eQTL）的结果以及功能基因组学数据，有助于理解 GWAS 和 eQTL 的结果以及功能基因组学数据。
可用性和实现：HUGIn 可在 http://yunliweb.its.unc.edu/HUGIn 上获得。
联系方式：yunli@med.unc.edu 或 hum@ccf.org。
补充信息：补充数据可在《生物信息学》在线获取。
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