Huang Shu Ran, Ma Ai Ying, Liu Yuan, Qu Yan
Department of Intensive Care Unit, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, Shandong 266071, P.R. China.
Department of Intensive Care Unit, The Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China.
Oncol Lett. 2017 Jun;13(6):5016-5020. doi: 10.3892/ol.2017.6090. Epub 2017 Apr 25.
The present study investigated the association between the levels of plasma tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-8, high-sensitivity C-reactive protein and fibrinogen levels of patients with acute respiratory distress syndrome (ARDS) with ARDS treatment outcome and duration of mechanical ventilation, with the aim of improving the efficacy of ARDS therapy. A total of 140 patients with ARDS were randomly divided into groups A and B, with 70 patients in each group. The patients in group A received a combination of conventional treatment and comprehensive treatment (test group) and the patients in group B were treated with conventional therapy only (control group). Elbow venous blood was obtained from each patient in the morning prior to treatment, on the 3rd day of treatment and on the 5th day of treatment. The levels of inflammatory factors, the clinical effects and the duration of mechanical ventilation of the two groups were statistically analyzed. The levels of IL-6, TNF-α and IL-8 in patients from group A were significantly reduced compared with those from group B (P<0.05). Additionally, the oxygenation index and arterial partial oxygen pressure of patients in group A were significantly higher compared with group B patients (P<0.05), the duration of mechanical ventilation of group A was decreased compared with that of group B (P<0.05) and the overall response rate of group A was >90%, whereas group B had a response rate of 80.0%. These results indicate that the treatment administered to patients in group A exhibited an improved clinical efficacy. The combination of comprehensive and conventional therapy may effectively reduce the levels of inflammatory factors and the inflammatory response, and these levels may be important for the effective treatment of ARDS and in reducing treatment duration. Therefore the current study may improve upon current clinical practice.
本研究调查了急性呼吸窘迫综合征（ARDS）患者血浆肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6、IL-8、高敏C反应蛋白水平及纤维蛋白原水平与ARDS治疗效果和机械通气时间的相关性，旨在提高ARDS治疗的疗效。总共140例ARDS患者被随机分为A组和B组，每组70例。A组患者接受常规治疗与综合治疗相结合（试验组），B组患者仅接受常规治疗（对照组）。在治疗前、治疗第3天和治疗第5天的早晨，从每位患者的肘静脉采集血液。对两组患者的炎症因子水平、临床疗效和机械通气时间进行统计学分析。与B组患者相比，A组患者的IL-6、TNF-α和IL-8水平显著降低（P<0.05）。此外，A组患者的氧合指数和动脉血氧分压显著高于B组患者（P<0.05），A组的机械通气时间较B组缩短（P<0.05），A组的总有效率>90%，而B组的有效率为80.0%。这些结果表明，给予A组患者的治疗显示出更好的临床疗效。综合治疗与常规治疗相结合可有效降低炎症因子水平和炎症反应，这些水平对于ARDS的有效治疗和缩短治疗时间可能很重要。因此，本研究可能改进当前的临床实践。
