Dortet Laurent, Bernabeu Sandrine, Gonzalez Camille, Naas Thierry
Bacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
EA7361 "Structure, dynamic, function and expression of broad spectrum β-lactamases," Paris-Sud University, LabEx Lermit, Faculty of Medecine, Le Kremlin-Bicêtre, France.
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00796-17. Print 2017 Aug.
A novel algorithm designed for the screening of carbapenemase-producing (CPE), based on faropenem and temocillin disks, was compared to that of the Committee of the Antibiogram of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem, and temocillin disks. The two algorithms presented comparable negative predictive values (98.6% versus 97.5%) for CPE screening among carbapenem-nonsusceptible However, since 46.2% ( = 49) of the CPE were correctly identified as OXA-48-like producers by the faropenem/temocillin-based algorithm, it significantly decreased the number of complementary tests needed (42.2% versus 62.6% with the CA-SFM algorithm).
一种基于法罗培南和替莫西林纸片设计的用于筛查产碳青霉烯酶（CPE）的新型算法，与法国微生物学会抗菌谱委员会（CA-SFM）基于替卡西林-克拉维酸、亚胺培南和替莫西林纸片的算法进行了比较。在对碳青霉烯不敏感的菌株中，两种算法在CPE筛查方面呈现出相当的阴性预测值（分别为98.6%和97.5%）。然而，由于基于法罗培南/替莫西林的算法能将46.2%（即49株）的CPE正确鉴定为OXA-48样产酶株，它显著减少了所需补充检测的数量（与CA-SFM算法相比，分别为42.2%和62.6%）。
