Siengsukon Catherine F, Aldughmi Mayis, Kahya Melike, Bruce Jared, Lynch Sharon, Ness Norouzinia Abigail, Glusman Morgan, Billinger Sandra
Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, USA.
Department of Psychology, University of Missouri-Kansas City, USA.
Mult Scler J Exp Transl Clin. 2016 Nov 24;2:2055217316680639. doi: 10.1177/2055217316680639. eCollection 2016 Jan-Dec.
Nearly 70% of individuals with multiple sclerosis (MS) experience sleep disturbances. Increasing physical activity in people with MS has been shown to produce a moderate improvement in sleep quality, and exercise has been shown to improve sleep quality in non-neurologically impaired adults.
The purpose of this pilot randomized controlled trial study was to examine the effect of two exercise interventions on sleep quality and daytime sleepiness in individuals with MS.
Twenty-eight individuals with relapsing-remitting or secondary progressive MS were randomized into one of two 12-week exercise interventions: a supervised, moderate-intensity aerobic exercise (AE) program or an unsupervised, low-intensity walking and stretching (WS) program. Only individuals who were ≥ 70% compliant with the programs were included in analysis ( = 12 AE; = 10 WS).
Both groups demonstrated a moderate improvement in sleep quality, although only the improvement by the WS group was statistically significant. Only the AE group demonstrated a significant improvement in daytime sleepiness. Change in sleep quality and daytime sleepiness was not correlated with disease severity or with change in cardiovascular fitness, depression, or fatigue.
The mechanisms for improvement in sleep quality and daytime sleepiness need further investigation, but may be due to introduction of zeitgebers to improve circadian rhythm.
近70%的多发性硬化症（MS）患者存在睡眠障碍。研究表明，增加MS患者的身体活动能适度改善睡眠质量，并且运动已被证明可改善无神经功能障碍成年人的睡眠质量。
这项初步随机对照试验研究的目的是检验两种运动干预措施对MS患者睡眠质量和日间嗜睡的影响。
28例复发缓解型或继发进展型MS患者被随机分为两种为期12周的运动干预措施之一：有监督的中等强度有氧运动（AE）计划或无监督的低强度步行和伸展（WS）计划。仅将依从性≥70%的患者纳入分析（AE组=12例；WS组=10例）。
两组的睡眠质量均有适度改善，不过只有WS组的改善具有统计学意义。只有AE组的日间嗜睡有显著改善。睡眠质量和日间嗜睡的变化与疾病严重程度或心血管健康状况、抑郁或疲劳的变化无关。
睡眠质量和日间嗜睡改善的机制需要进一步研究，但可能是由于引入了授时因子以改善昼夜节律。
