Zhao Jiulong, Zhou Chunhua, Li Mao, Li Jialing, Li Guixiang, Ma Dan, Li Zhaoshen, Zou Duowu
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Department of Gastroenterology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Oncotarget. 2017 Nov 8;8(63):106707-106720. doi: 10.18632/oncotarget.22477. eCollection 2017 Dec 5.
The two-dimensional molybdenum disulfide (MoS) nanosheet has been extensively studied as a novel photothermal transducing agent. However, top-down exfoliation to produce MoS nanosheets is inefficient, and MoS nanosheet surface modification procedures are complex. Here, we report the synchronous synthesis and surface modification of 2D MoS nanosheets with a polyvinylpyrrolidone (PVP)-assisted one-pot hydrothermal method. Due to the chelating-coordinating effect between the lone-pair electrons of the PVP carbonyl oxygen and the unoccupied 4d orbitals of molybdenum, the PVP chains could graft onto the surface of MoS and guide the growth of the nanosheets. The resultant MoS-PVP nanosheets were ultra-small (21.4 ± 4.4 nm) and exhibited excellent colloidal stability. Moreover, the strong near-infrared absorption of the MoS-PVP nanosheets enabled sensitive photothermal conversion performance (with a mass extinction coefficient of 23.33 L g cm) and / photoacoustic imaging. The MoS-PVP nanosheets had excellent and compatibility and were used for highly efficient tumor photothermal therapy in xenograft tumor-bearing mice. The findings in this report will facilitate the rational design of stable colloidal 2D transition-metal dichalcogenides for effective photothermal cancer therapy.
二维二硫化钼（MoS₂）纳米片作为一种新型光热转换剂已得到广泛研究。然而，通过自上而下剥落法制备MoS₂纳米片效率低下，且MoS₂纳米片的表面改性程序复杂。在此，我们报道了一种采用聚乙烯吡咯烷酮（PVP）辅助的一锅水热法同步合成和表面改性二维MoS₂纳米片的方法。由于PVP羰基氧的孤对电子与钼的空4d轨道之间的螯合配位作用，PVP链可以接枝到MoS₂表面并引导纳米片的生长。所得的MoS₂ - PVP纳米片超小（21.4 ± 4.4 nm），并表现出优异的胶体稳定性。此外，MoS₂ - PVP纳米片强烈的近红外吸收使其具有灵敏的光热转换性能（质量消光系数为23.33 L g⁻¹ cm⁻¹）和光声成像能力。MoS₂ - PVP纳米片具有优异的生物相容性，用于荷瘤裸鼠的高效肿瘤光热治疗。本报告中的研究结果将有助于合理设计稳定的胶体二维过渡金属二硫属化物用于有效的光热癌症治疗。
