Omrani Mohsen, Kaufman Matthew T, Hatsopoulos Nicholas G, Cheney Paul D
Brain Health Institute, Rutgers University, Piscataway, New Jersey;
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
J Neurophysiol. 2017 Sep 1;118(3):1828-1848. doi: 10.1152/jn.00795.2016. Epub 2017 Jun 14.
Primary motor cortex has been studied for more than a century, yet a consensus on its functional contribution to movement control is still out of reach. In particular, there remains controversy as to the level of control produced by motor cortex ("low-level" movement dynamics vs. "high-level" movement kinematics) and the role of sensory feedback. In this review, we present different perspectives on the two following questions: What does activity in motor cortex reflect? and How do planned motor commands interact with incoming sensory feedback during movement? The four authors each present their independent views on how they think the primary motor cortex (M1) controls movement. At the end, we present a dialogue in which the authors synthesize their views and suggest possibilities for moving the field forward. While there is not yet a consensus on the role of M1 or sensory feedback in the control of upper limb movements, such dialogues are essential to take us closer to one.
初级运动皮层已经被研究了一个多世纪,但对于其在运动控制中的功能贡献仍未达成共识。特别是,关于运动皮层产生的控制水平(“低水平”运动动力学与“高水平”运动运动学)以及感觉反馈的作用仍存在争议。在这篇综述中,我们针对以下两个问题呈现了不同的观点:运动皮层的活动反映了什么?以及在运动过程中,计划好的运动指令如何与传入的感觉反馈相互作用?四位作者各自就他们认为初级运动皮层(M1)如何控制运动提出了独立的观点。最后,我们呈现了一段对话,在对话中作者们综合了他们的观点,并提出了推动该领域向前发展的可能性。虽然对于M1或感觉反馈在上肢运动控制中的作用尚未达成共识,但这样的对话对于使我们更接近达成共识至关重要。