逃避mTOR抑制用于癌症治疗：mTOR的肿瘤抑制功能
Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR.
作者信息
Villar Victor H, Nguyen Tra Ly, Terés Silvia, Bodineau Clément, Durán Raúl V
机构信息
Institut Européen de Chimie et Biologie, Pessac, France.
Institut Bergonié, ACTION Unit U1218 INSERM, Bordeaux, France.
出版信息
Mol Cell Oncol. 2017 Mar 3;4(3):e1297284. doi: 10.1080/23723556.2017.1297284. eCollection 2017.
Abstract
A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic.
摘要
作为细胞生长的主要促进因子，哺乳动物雷帕霉素靶蛋白（mTOR）在很大比例的癌细胞中表达上调。然而，使用雷帕霉素靶向mTOR在患者中的治疗效果有限。我们最近的研究结果突出了mTOR作为肿瘤抑制因子的额外作用，解释了其在临床上效果不佳的原因。
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