Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen , 9700 AD Groningen, The Netherlands.
TI-COAST , Science Park 904, 1098 XH Amsterdam, The Netherlands.
Anal Chem. 2017 Jul 5;89(13):7053-7061. doi: 10.1021/acs.analchem.7b00828. Epub 2017 Jun 19.
In this work, the use of fused deposition modeling (FDM) in a (bio)analytical/lab-on-a-chip research laboratory is described. First, the specifications of this 3D printing method that are important for the fabrication of (micro)devices were characterized for a benchtop FDM 3D printer. These include resolution, surface roughness, leakage, transparency, material deformation, and the possibilities for integration of other materials. Next, the autofluorescence, solvent compatibility, and biocompatibility of 12 representative FDM materials were tested and evaluated. Finally, we demonstrate the feasibility of FDM in a number of important applications. In particular, we consider the fabrication of fluidic channels, masters for polymer replication, and tools for the production of paper microfluidic devices. This work thus provides a guideline for (i) the use of FDM technology by addressing its possibilities and current limitations, (ii) material selection for FDM, based on solvent compatibility and biocompatibility, and (iii) application of FDM technology to (bio)analytical research by demonstrating a broad range of illustrative examples.
本工作描述了在（生物）分析/片上实验室中使用熔融沉积成型（FDM）技术。首先，我们对台式 FDM 3D 打印机的这项 3D 打印方法的重要规格进行了表征，这些规格包括分辨率、表面粗糙度、泄漏、透明度、材料变形以及集成其他材料的可能性。接下来，我们测试并评估了 12 种代表性 FDM 材料的自发荧光、溶剂兼容性和生物相容性。最后，我们展示了 FDM 在一些重要应用中的可行性。具体而言，我们考虑了用于制造流道、聚合物复制母版以及用于制作纸微流控器件的工具。因此，这项工作为（i）通过解决其可能性和当前局限性来使用 FDM 技术，（ii）基于溶剂兼容性和生物相容性的 FDM 材料选择，以及（iii）通过展示广泛的说明性示例来将 FDM 技术应用于（生物）分析研究提供了一个指南。
