去甲肾上腺素在体内增加大鼠肩胛间棕色脂肪组织中丙酮酸脱氢酶活性并降低乙酰辅酶A羧化酶活性的证据。
Evidence that noradrenaline increases pyruvate dehydrogenase activity and decreases acetyl-CoA carboxylase activity in rat interscapular brown adipose tissue in vivo.
作者信息
Gibbins J M, Denton R M, McCormack J G
出版信息
Biochem J. 1985 Jun 15;228(3):751-5. doi: 10.1042/bj2280751.
Abstract
The rate of fatty acid synthesis in interscapular brown adipose tissue of female cold-adapted rats, as measured by the incorporation of 3H from 3H2O into tissue lipid, was decreased by about 70% after injection of noradrenaline. There was a similar decrease in the activity of acetyl-CoA carboxylase. In contrast, the proportion of pyruvate dehydrogenase in its active non-phosphorylated form was greatly increased after injection of noradrenaline. This finding suggests that the oxidation of glucose may be important in noradrenaline-induced thermogenesis in rat brown adipose tissue.
摘要
通过测量从3H2O中掺入组织脂质的3H来测定，注射去甲肾上腺素后，雌性冷适应大鼠肩胛间棕色脂肪组织中的脂肪酸合成速率降低了约70%。乙酰辅酶A羧化酶的活性也有类似程度的降低。相反，注射去甲肾上腺素后，处于活性非磷酸化形式的丙酮酸脱氢酶比例大幅增加。这一发现表明，葡萄糖氧化在去甲肾上腺素诱导的大鼠棕色脂肪组织产热过程中可能很重要。
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