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普通狨猴的产热能力和棕色脂肪组织活性

Thermogenic capacity and brown adipose tissue activity in the common marmoset.

作者信息

Rothwell N J, Stock M J

出版信息

Comp Biochem Physiol A Comp Physiol. 1985;81(3):683-6. doi: 10.1016/0300-9629(85)91047-3.

DOI:10.1016/0300-9629(85)91047-3
PMID:2863059
Abstract

Resting oxygen consumption was measured in anaesthetized male and female common marmosets (Callithrix jacchus) at 29 degrees C. Injection of noradrenaline caused a marked increase in oxygen consumption (63%), but this response was lower in males. Large deposits (750 mg) of brown adipose tissue (BAT) were dissected from the cervical, subscapular, axillary and perirenal areas. High levels of guanosine diphosphate binding to isolated brown fat mitochondria were observed, indicating that the thermogenic proton conductance pathway is very active in brown fat from the marmoset. High levels of brown adipose tissue thermogenesis in these animals may be related to a requirement for diet-induced thermogenesis.

摘要

在29摄氏度下,对麻醉状态的雄性和雌性普通狨猴(Callithrix jacchus)测量静息耗氧量。注射去甲肾上腺素导致耗氧量显著增加(63%),但雄性的这种反应较低。从颈部、肩胛下、腋窝和肾周区域解剖出大量(750毫克)棕色脂肪组织(BAT)。观察到分离的棕色脂肪线粒体中鸟苷二磷酸结合水平很高,这表明产热质子传导途径在狨猴的棕色脂肪中非常活跃。这些动物中高水平的棕色脂肪组织产热可能与饮食诱导产热的需求有关。

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