School of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning, 110122, China.
Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, Shenyang, Liaoning, 110122, China.
Sci Rep. 2017 Jun 20;7(1):3902. doi: 10.1038/s41598-017-04252-0.
There is no consensus on the involvement of zinc (Zn) dysfunctions in Parkinson's Disease (PD). We performed a meta-analysis to evaluate whether circulating Zn levels in the serum, plasma, and cerebrospinal fluid (CSF) are altered in PD. Twenty-three published studies were selected by searching the databases of PubMed and China National Knowledge Infrastructure (CNKI). A total of 803 PD patients and 796 controls, 342 PD patients and 392 controls, and 135 PD patients and 93 controls were included to study Zn levels in the serum, plasma, and CSF, respectively. Our meta-analysis showed that the serum Zn levels were significantly lower in PD patients compared with health controls (SMD = -0.59; 95% CI [-1.06, -0.12]; P = 0.014). A reduced Zn levels in PD patients were found when serum and plasma studies were analyzed together (SMD = -0.60, 95% CI [-0.98; -0.22]; p = 0.002). PD patients had a tendency toward reduced CSF Zn levels compared with health controls (SMD = -0.50; 95% CI [-1.76, 0.76]; P = 0.439), but no statistical significance was obtained and this data did not allow conclusions due to a small sample size of CSF studies. This study suggests that reduced Zn levels in the serum and plasma are associated with an increased risk for PD.
目前，人们对于锌（Zn）功能紊乱是否与帕金森病（PD）相关仍存在争议。我们进行了一项荟萃分析，以评估 PD 患者的血清、血浆和脑脊液（CSF）中循环 Zn 水平是否发生改变。通过检索 PubMed 和中国知网（CNKI）数据库，我们筛选出 23 项已发表的研究。共有 803 名 PD 患者和 796 名对照者、342 名 PD 患者和 392 名对照者、135 名 PD 患者和 93 名对照者分别被纳入研究血清、血浆和 CSF 中的 Zn 水平。我们的荟萃分析显示，PD 患者的血清 Zn 水平明显低于健康对照者（SMD=-0.59；95%CI[-1.06，-0.12]；P=0.014）。当综合分析血清和血浆研究时，发现 PD 患者的 Zn 水平降低（SMD=-0.60，95%CI[-0.98；-0.22]；p=0.002）。与健康对照者相比，PD 患者的 CSF Zn 水平有降低的趋势（SMD=-0.50；95%CI[-1.76，0.76]；P=0.439），但由于 CSF 研究的样本量较小，未得出统计学意义，且该数据不允许得出结论。本研究表明，血清和血浆中 Zn 水平降低与 PD 的发病风险增加相关。
