Center for Programmable Materials, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis #08-03, Singapore, 138634, Singapore.
Adv Mater. 2017 Aug;29(32). doi: 10.1002/adma.201700102. Epub 2017 Jun 21.
Inspired by the multiple functions of natural multienzyme systems, a new kind of hybrid nanosheet is designed and synthesized, i.e., ultrasmall Au nanoparticles (NPs) grown on 2D metalloporphyrinic metal-organic framework (MOF) nanosheets. Since 2D metalloporphyrinic MOF nanosheets can act as the peroxidase mimics and Au NPs can serve as artificial glucose oxidase, the hybrid nanosheets are used to mimic the natural enzymes and catalyze the cascade reactions. Furthermore, the synthesized hybrid nanosheets are used to detect biomolecules, such as glucose. This study paves a new avenue to design nanomaterial-based biomimetic catalysts with multiple complex functions.
受天然多酶体系的多种功能启发，设计并合成了一种新型杂化纳米片，即生长在二维金属卟啉金属-有机骨架（MOF）纳米片上的超小金纳米颗粒（NPs）。由于二维金属卟啉 MOF 纳米片可以作为过氧化物酶模拟物，而 Au NPs 可以作为人工葡萄糖氧化酶，因此杂化纳米片可用于模拟天然酶并催化级联反应。此外，所合成的杂化纳米片还可用于检测生物分子，如葡萄糖。这项研究为设计具有多种复杂功能的基于纳米材料的仿生催化剂开辟了新途径。
