Wagner Vivian Petersen, Webber Liana Preto, Ortiz Lisley, Rados Pantelis Varvaki, Meurer Luise, Lameira Osmar Alves, Lima Rafael Rodrigues, Martins Manoela Domingues
Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.
Experimental Pathology Unit, Clinics Hospital of Porto Alegre, Federal University of Rio, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.
Phytother Res. 2017 Aug;31(8):1283-1288. doi: 10.1002/ptr.5845. Epub 2017 Jun 21.
The effects of topical copaiba oil extract and topical corticosteroid were assessed on oral wound healing in an in vivo model using 96 male Wistar rats. Traumatic ulcers were caused in the dorsum of the tongue using a 3-mm punch tool. The animals were divided into: Control; Corticosteroid; Placebo and Copaiba oil Group. The animals received two daily applications of the products. The control group received only daily handling. Six rats in each group were euthanized at days 3, 5, 10 and 14. The animals were monitored daily to determine wound status. The weigh was assessed at day 0 and euthanasia day. The percentage of repair was calculated, and histopathological aspects were analyzed. The Kruskal-Wallis test was used to compare the results between groups and times of evaluation. Closing time was assessed through the log-rank test. The corticosteroid group lost more weight at days 10 and 14 than the control group (p < 0.05). Moreover, the healing time of corticosteroid group was longer than the control group (p = 0.007). No differences were observed between the copaiba oil group and the control group. We concluded that topical copaiba oil, in spite of being safe, did not accelerate the process of oral wound healing. Copyright © 2017 John Wiley & Sons, Ltd.
在一个体内模型中，使用96只雄性Wistar大鼠评估了局部应用巴西香脂油提取物和局部应用皮质类固醇对口腔伤口愈合的影响。使用3毫米打孔工具在大鼠舌背造成创伤性溃疡。将动物分为：对照组；皮质类固醇组；安慰剂组和巴西香脂油组。动物每天接受两次产品涂抹。对照组仅接受每日处理。每组在第3、5、10和14天处死6只大鼠。每天监测动物以确定伤口状况。在第0天和安乐死当天评估体重。计算修复百分比，并分析组织病理学方面。使用Kruskal-Wallis检验比较组间和评估时间的结果。通过对数秩检验评估愈合时间。皮质类固醇组在第10天和第14天比对照组体重减轻更多（p<0.05）。此外，皮质类固醇组的愈合时间比对照组更长（p = 0.007）。在巴西香脂油组和对照组之间未观察到差异。我们得出结论，局部应用巴西香脂油尽管安全，但并未加速口腔伤口愈合过程。版权所有©2017约翰威立父子有限公司。
