Yolbaş Servet, Gözel Nevzat, Dağlı Mustafa Necati, Koca Süleyman Serdar, Dönder Emir
Department of Rheumatology, İnönü University School of Medicine, Malatya, Turkey.
Department of Internal Medicine, Fırat University School of Medicine, Elazığ, Turkey.
Eur J Rheumatol. 2017 Jun;4(2):122-126. doi: 10.5152/eurjrheum.2017.160096. Epub 2017 Jun 1.
Increased carotid arterial stiffness (CAS) is a predictor of subclinical early atherosclerosis as well as carotid intima-media thickness (cIMT). We aimed to determine CAS and cIMT in Behçet's disease (BD).
BD (n=49) and rheumatoid arthritis (RA) (n=64) patients and healthy controls (HC) (n=40) were included in the study. cIMT was measured. CAS indices, including arterial compliance (AC), arterial distensibility (AD), Young's elastic modulus (YEM), Peterson's elastic modulus (Ep), and β stiffness index (βSI) were measured based on the diameter-pressure relationship.
When compared to the HC group, the mean cIMT was significantly higher in the RA group (p=0.033), but it was not higher in the BD group. The CAS indices, including AD, AC, Ep, and βSI were not significantly different among the study groups. Moreover, the cIMT and CAS indices were not significantly different between active (n=20) and inactive BD patients, and these indices were not correlated with the scores of disease activity. AD, AC and Ep were significantly lower in the BD patients with a positive pathergy reaction than in those with a negative reaction.
These results suggest that BD does not directly lead to arterial stiffness or to an increase in cIMT.
颈动脉僵硬度（CAS）增加是亚临床早期动脉粥样硬化以及颈动脉内膜中层厚度（cIMT）的一个预测指标。我们旨在测定白塞病（BD）患者的CAS和cIMT。
本研究纳入了49例BD患者、64例类风湿关节炎（RA）患者以及40例健康对照（HC）。测量cIMT。基于直径-压力关系测量CAS指数，包括动脉顺应性（AC）、动脉扩张性（AD）、杨氏弹性模量（YEM）、彼得森弹性模量（Ep）和β僵硬度指数（βSI）。
与HC组相比，RA组的平均cIMT显著更高（p = 0.033），但BD组并非如此。包括AD、AC、Ep和βSI在内的CAS指数在各研究组之间无显著差异。此外，活动期（n = 20）和非活动期BD患者的cIMT和CAS指数无显著差异，且这些指数与疾病活动评分无关。有针刺反应阳性的BD患者的AD、AC和Ep显著低于针刺反应阴性的患者。
这些结果表明，BD不会直接导致动脉僵硬度增加或cIMT升高。
