School Sport, Exercise & Health Sciences, National Centre for Sport and Exercise Medicine - East Midlands, Loughborough University, Loughborough LE11 3TU, United Kingdom; Department of Epidemiology and Public Health, University College London, London, United Kingdom; NIHR Leicester Biomedical Research Centre, United Kingdom.
NIHR Leicester Biomedical Research Centre, United Kingdom; University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, United Kingdom.
Atherosclerosis. 2017 Aug;263:151-155. doi: 10.1016/j.atherosclerosis.2017.06.024. Epub 2017 Jun 9.
Television (TV) viewing is a major component of leisure sedentary time, and has been consistently associated with cardiovascular disease. We examined the extent to which metabolic biomarkers explain the association between TV viewing and mortality.
Participants (N = 8,451, aged 64.8 ± 9.9 yrs) were drawn from The English Longitudinal Study of Ageing (ELSA), a national prospective cohort study of community-dwelling men and women living in England. The individual participant data were linked with death records from the National Health Service registries from 2008 to 2012. Cox proportional hazards models were used to estimate the risk of death according to time spent watching TV, with biomarkers added in a stepwise fashion to estimate potential mediation.
Over an average follow up of 4 years (33,832 person years), there were 370 deaths. In models adjusted for comorbidities, psychosocial factors, and health behaviours including physical activity, there was an association between TV viewing and mortality (≥6 h per day vs. < 2 h per day [Ref]; hazard ratio = 1.98, 95% CI, 1.25, 3.15). Adjustment for inflammatory markers (C-reactive protein and fibrinogen) accounted for ∼15.7% of the association between TV viewing and mortality, but metabolic risk factors (HDL-cholesterol, triglycerides, glycated haemoglobin) did not contribute.
The association between TV viewing and mortality was partly mediated by inflammatory markers, although the relationship remains largely unexplained.
看电视是休闲时间久坐行为的主要组成部分，并且一直与心血管疾病有关。我们研究了代谢生物标志物在多大程度上解释了看电视与死亡率之间的关联。
参与者（N=8451 人，年龄 64.8±9.9 岁）来自英国全国社区居住的男性和女性的老龄化纵向研究（ELSA），这是一项前瞻性队列研究。将个体参与者数据与 2008 年至 2012 年期间国家卫生服务登记处的死亡记录进行了关联。使用 Cox 比例风险模型根据看电视的时间来估计死亡风险，逐步加入生物标志物来估计潜在的中介作用。
在平均 4 年（33832 人年）的随访中，有 370 人死亡。在调整了合并症、心理社会因素以及包括身体活动在内的健康行为后，看电视与死亡率之间存在关联（每天≥6 小时与每天<2 小时[参照]；危险比=1.98，95%置信区间，1.25，3.15）。调整炎症标志物（C 反应蛋白和纤维蛋白原）后，看电视与死亡率之间的关联约有 15.7%可归因于炎症标志物，但代谢危险因素（高密度脂蛋白胆固醇、甘油三酯、糖化血红蛋白）则没有。
看电视与死亡率之间的关联部分是由炎症标志物介导的，尽管这种关系在很大程度上仍未得到解释。
