Brandwein Michael, Steinberg Doron, Meshner Shiri
Faculty of Dental Medicine, The Hebrew University of Jerusalem, Hadassah Ein Kerem, Jerusalem, Israel.
Dead Sea and Arava Science Center, The Dead Sea Microbiology lab, Ein Gedi, Israel.
NPJ Biofilms Microbiomes. 2016 Nov 23;2:3. doi: 10.1038/s41522-016-0004-z. eCollection 2016.
The human skin microbiome plays an important role in both health and disease. Microbial biofilms are a well-characterized mode of surface-associated growth, which present community-like behaviors. Additionally, biofilms are a critical element in certain skin diseases. We review how the perception of the resident skin microbiota has evolved from the early linkages of certain microbes to disease states, to a more comprehensive and intricate understanding brought on by biofilm and microbiome revelations. Rapidly expanding arsenals of experimental methods are opening new horizons in the study of human-microbe and microbe-microbe interactions. Microbial community profiling has largely remained a separate discipline from that of biofilm research, yet the introduction of metatranscriptomics, metabolomics, and the ability to distinguish between dormant and active members of a community have all paved the road toward a convergent cognizance of the encounter between these two microbial disciplines.
人类皮肤微生物群落在健康和疾病中都起着重要作用。微生物生物膜是一种特征明确的与表面相关的生长模式，呈现出群落样行为。此外，生物膜是某些皮肤疾病的关键因素。我们回顾了常驻皮肤微生物群的认知是如何从某些微生物与疾病状态的早期联系，发展到由生物膜和微生物群揭示所带来的更全面、更复杂的理解。迅速扩充的实验方法正在为人类-微生物和微生物-微生物相互作用的研究开辟新的视野。微生物群落分析在很大程度上仍是一个与生物膜研究分开的学科，但宏转录组学、代谢组学的引入以及区分群落中休眠成员和活跃成员的能力，都为这两个微生物学科之间的交汇认知铺平了道路。
