Hamsten A, Svensson J, Walldius G, Szamosi A, de Faire U
Am Heart J. 1985 Dec;110(6):1154-60. doi: 10.1016/0002-8703(85)90005-5.
Megakaryocyte-platelet regeneration time (MPRT) was determined 6 to 12 months after myocardial infarction in 42 patients below the age of 45 years (mean age +/- SD = 39.4 +/- 4.6, range 23 to 44) and in 11 healthy control subjects by measurement of the reappearance rate of platelet cyclooxygenase activity after oral aspirin. In the young post infarction patients, MPRT was correlated to pertinent metabolic, angiographic, and clinical findings. MPRT for all patients tended to be shorter than in control subjects (t1/2 = 4.53 +/- 1.15 vs 5.22 +/- 0.52; p less than 0.10). Age, present tobacco consumption, serum lipoprotein lipid concentrations, and glucose tolerance, as well as other measured risk factors, did not correlate significantly with MPRT. A marked difference in MPRT, independent of risk factor profile, was present between patients with and without hemodynamically significant stenoses in the coronary angiogram (4.06 +/- 0.92 vs 5.22 +/- 1.07; p less than 0.001). It is suggested that a shortened platelet survival in young post infarction patients is secondary to platelet activation by high-velocity flow and shear forces at the sites of proximal coronary artery stenoses.
在42名年龄小于45岁（平均年龄±标准差 = 39.4±4.6，范围23至44岁）的心肌梗死患者以及11名健康对照者中，通过测量口服阿司匹林后血小板环氧化酶活性的再现率，在心肌梗死后6至12个月测定巨核细胞 - 血小板再生时间（MPRT）。在年轻的心肌梗死后患者中，MPRT与相关的代谢、血管造影和临床发现相关。所有患者的MPRT往往比对照者短（t1/2 = 4.53±1.15对5.22±0.52；p＜0.10）。年龄、当前烟草消费量、血清脂蛋白脂质浓度和葡萄糖耐量以及其他测量的危险因素与MPRT均无显著相关性。在冠状动脉造影中有或无血流动力学显著狭窄的患者之间，MPRT存在明显差异，与危险因素谱无关（4.06±0.92对5.22±1.07；p＜0.001）。提示年轻心肌梗死后患者血小板存活时间缩短是由于冠状动脉近端狭窄部位的高速血流和剪切力导致血小板活化所致。
