Hierlemann Andreas
ETH Zurich, Department of Biosystems Science and Engineering, CH-4058, Basel, Switzerland
Proc IEEE Int Conf Micro Electro Mech Syst. 2017 Feb 28;2017:199-204. doi: 10.1109/MEMSYS.2017.7863375.
The use of large high-density transducer arrays enables fundamentally new neuroscientific insights through enabling high-throughput monitoring of action potentials of larger neuronal networks (> 1000 neurons) over extended time to see effects of disturbances or developmental effects, and through facilitating detailed investigations of neuronal signaling characteristics at subcellular level, for example, the study of axonal signal propagation that has been largely inaccessible to established methods. Applications include research in neural diseases and pharmacology.
使用大型高密度换能器阵列能够带来全新的神经科学见解，这是通过对更大的神经元网络（超过1000个神经元）的动作电位进行高通量监测，以在较长时间内观察干扰效应或发育效应来实现的，还通过促进在亚细胞水平对神经元信号特征进行详细研究来实现，例如，对轴突信号传播的研究，而这在很大程度上是现有方法无法做到的。其应用包括神经疾病和药理学研究。
