Nojiri Shuko, Daida Hiroyuki
Clinical Research Support Center, Juntendo University, Tokyo, Japan.
Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine Tokyo, Japan.
Jpn Clin Med. 2017 Jun 19;8:1179066017712713. doi: 10.1177/1179066017712713. eCollection 2017.
Increased global mortality is associated with atherosclerosis, which appears to be independent of race. Cardiovascular disease is one of the leading causes of mortality and morbidity in Japan. Atherosclerosis, an inflammatory disease characterized by abnormal lipid accumulation and inflammation in the arterial wall, is the main underlying cause of cardiovascular disease. Numerous cardiovascular risk scores have been developed and are used to prioritize patients' treatment needs. The predictive performance of risk scores established in Western nations needs to be examined in Japanese populations. For secondary prevention, it is imperative to control hypertension, hyperlipidemia, diabetes mellitus, smoking, and local interventions. In this review, we present a historical overview of atherosclerotic risk research and the risk factors for atherosclerosis in Japan and compare the situation in Japan with that in Western nations. In addition, we discuss relevant cardiovascular risk assessment tools in the context of clinical practice in Japan.
全球死亡率上升与动脉粥样硬化相关，而动脉粥样硬化似乎与种族无关。心血管疾病是日本死亡和发病的主要原因之一。动脉粥样硬化是一种以动脉壁脂质异常积聚和炎症为特征的炎症性疾病，是心血管疾病的主要潜在病因。已经开发了许多心血管风险评分，并用于确定患者的治疗需求优先级。在日本人群中需要检验在西方国家建立的风险评分的预测性能。对于二级预防，控制高血压、高脂血症、糖尿病、吸烟以及局部干预至关重要。在本综述中，我们介绍了日本动脉粥样硬化风险研究的历史概况以及动脉粥样硬化的风险因素，并将日本的情况与西方国家进行比较。此外，我们在日本临床实践的背景下讨论了相关的心血管风险评估工具。
