Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27606, USA.
Chemphyschem. 2021 Dec 13;22(24):2526-2534. doi: 10.1002/cphc.202100667. Epub 2021 Oct 26.
We introduce a Spin Transfer Automated Reactor (STAR) that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the PHIP variant called signal amplification by reversible exchange (SABRE), which is particularly well suited to produce continuous hyperpolarization. The STAR is operated in conjunction with benchtop (1.1 T) and high field (9.4 T) NMR magnets, highlighting the versatility of this system to operate with any NMR or MRI system. The STAR uses semipermeable membranes to efficiently deliver parahydrogen into solutions at nano to milli Tesla fields, which enables H, C, and N hyperpolarization on a large range of substrates including drugs and metabolites. The unique features of the STAR are leveraged for important applications, including continuous hyperpolarization of metabolites, desirable for examining steady-state metabolism in vivo, as well as for continuous RASER signals suitable for the investigation of new physics.
我们介绍了一种自旋转移自动反应器（STAR），它可以产生连续的 Para 氢诱导极化（PHIP），这种极化状态稳定数小时到数天。我们使用了一种称为信号放大可逆交换（SABRE）的 PHIP 变体，它特别适合产生连续的超极化。STAR 与台式（1.1T）和高场（9.4T）NMR 磁铁一起使用，突出了该系统与任何 NMR 或 MRI 系统一起使用的多功能性。STAR 使用半透膜将 Para 氢气有效地输送到纳特斯拉到毫特斯拉场的溶液中，这使得 H、C 和 N 能够在包括药物和代谢物在内的广泛基质上进行超极化。STAR 的独特功能被用于重要的应用，包括代谢物的连续超极化，这对于研究体内稳态代谢以及用于研究新物理的连续 RASER 信号是很有必要的。
