Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Int J Biol Macromol. 2017 Nov;104(Pt A):1003-1011. doi: 10.1016/j.ijbiomac.2017.06.124. Epub 2017 Jul 3.
Chitosan (CS) is a carbohydrate biopolymer, which has been known as a biological material in promoting the healing process of soft and hard connective tissues. It is biocompatible, biodegradable, bioactive, non-toxic, non-expensive and non-immunogenic, with antibacterial capability. Additionally, the capacity of forming complexes with other anionic biomaterials and molecules offers CS the characteristics to be used in biomedical applications. Therefore, this natural polysaccharide has widely been used as a wound dressing and in bone and cartilage regeneration because of these considerable properties. However, some studies have showed limited value in application of CS in tissue regeneration. It has been used alone or in combination with other biopolymers, bioceramics, or promotive growth factors to enhance regeneration of the soft and hard connective tissues. This study has reviewed various forms of CS including hydrogels, sponges, films, and nanofiber membranes. The role of CS alone or in combined form with other materials has also been reviewed in healing and regeneration of the cutaneous, cartilage and bone wounds. In addition, the present study has attempted to clarify the controversies and conflicts regarding effectiveness of CS in the healing process.
壳聚糖（CS）是一种碳水化合物生物聚合物，已被公认为一种促进软、硬结缔组织愈合过程的生物材料。它具有生物相容性、可生物降解、生物活性、无毒、廉价和非免疫原性，具有抗菌能力。此外，与其他阴离子生物材料和分子形成复合物的能力使 CS 具有用于生物医学应用的特性。因此，由于这些相当大的特性，这种天然多糖已广泛用作伤口敷料，并用于骨和软骨再生。然而，一些研究表明 CS 在组织再生中的应用价值有限。它已被单独或与其他生物聚合物、生物陶瓷或促进生长因子一起使用，以增强软、硬结缔组织的再生。本研究综述了各种形式的 CS，包括水凝胶、海绵、薄膜和纳米纤维膜。还综述了 CS 单独或与其他材料组合在皮肤、软骨和骨伤口愈合和再生中的作用。此外，本研究试图阐明 CS 在愈合过程中的有效性的争议和冲突。
