Gualtieri C T, Schroeder S R, Hicks R E, Quade D
Arch Gen Psychiatry. 1986 Apr;43(4):335-40. doi: 10.1001/archpsyc.1986.01800040045007.
The results of a systematic neuroleptic withdrawal study in 38 mentally retarded children, adolescents, and young adults are described. The focus of the study was the occurrence of side effects of chronic neuroleptic treatment: tardive dyskinesia, transient withdrawal dyskinesia, nondyskinetic withdrawal symptoms, and a possible behavioral analogue of withdrawal dyskinesia. Transient side effects were noted in 34% of the subjects, and tardive dyskinesia in an equal proportion. The data suggest that cumulative neuroleptic dose may play a role as a risk factor in the development of severe tardive dyskinesia.
本文描述了一项针对38名智障儿童、青少年和青年进行的系统性抗精神病药物撤药研究结果。该研究的重点是慢性抗精神病药物治疗的副作用发生情况：迟发性运动障碍、短暂撤药运动障碍、非运动性撤药症状以及撤药运动障碍可能的行为类似物。34%的受试者出现了短暂性副作用，迟发性运动障碍的比例与之相同。数据表明，累积抗精神病药物剂量可能是严重迟发性运动障碍发生的一个风险因素。
