Lee P W, Yanagihara R, Gibbs C J, Gajdusek D C
Arch Virol. 1986;88(1-2):57-66. doi: 10.1007/BF01310890.
Weanling Fischer rats inoculated intramuscularly with Hantaan virus (strain 76-118) developed subclinical infections characterized by transient viremia and shedding of virus in saliva, persistence of virus in lung, pancreas, spleen and liver, and development of fluorescent and neutralizing antibodies in serum with immune complex deposition in lung. Viremia and virus shedding in saliva occurred 10 to 13 days after inoculation. Horizontal intracage transmission of infection occurred between 35 and 63 days post-inoculation, long after disappearance of virus in oropharyngeal secretions and blood. Multiple attempts to demonstrate infectious virus in feces and urine during this period were unsuccessful. The inability to detect virus in urine samples of experimentally infected rats may have resulted from intermittent or low-titered viruria. This contrasts sharply with the prolonged high-titered viruria reported in striped field mice (Apodemus agrarius) infected with Hantaan virus, suggesting differences in the mode(s) of virus transmission in nature.
给断奶的Fischer大鼠肌肉注射汉坦病毒（76 - 118株）后，它们会发生亚临床感染，其特征为短暂性病毒血症、唾液中病毒脱落、病毒在肺、胰腺、脾脏和肝脏中持续存在，血清中出现荧光抗体和中和抗体，且肺中有免疫复合物沉积。接种后10至13天出现病毒血症和唾液中病毒脱落。接种后35至63天发生笼内水平传播感染，此时口咽分泌物和血液中的病毒早已消失。在此期间多次尝试在粪便和尿液中检测传染性病毒均未成功。在实验感染大鼠的尿液样本中未能检测到病毒，可能是由于间歇性或低滴度病毒尿。这与感染汉坦病毒的条纹田鼠（黑线姬鼠）中报道的长时间高滴度病毒尿形成鲜明对比，表明自然界中病毒传播方式存在差异。
