亚种的全基因组序列，新型天然产物（生物）化学的丰富来源。
Complete Genome Sequence of Subsp. , A Rich Source of Novel Natural Product (Bio-)Chemistry.
作者信息
Kusserow Kalina, Gulder Tobias A M
机构信息
Biosystems Chemistry, Department of Chemistry and Center for Integrated Protein Science Munich (CIPSM), Technical University of Munich, Lichtenbergstraße 4, 85748 Garching, Germany.
出版信息
J Genomics. 2017 Jul 2;5:75-76. doi: 10.7150/jgen.19673. eCollection 2017.
Abstract
The soil dwelling actinomycete strain subsp. is the producer of the antiviral antibiotics kistamicin A and B. Genome sequencing and bioinformatic analysis revealed the presence of the kistamycin biosynthetic gene cluster responsible for the formation of these non-ribosomal peptides as well as an impressive number of yet uncharacterized biosynthetic pathways. This includes polyketide, ribosomal and non-ribosomal peptide and a large number of terpenoid biosynthetic loci encoding yet unknown natural products. The genomic data of this strain is thus a treasure trove for genome mining for novel functional metabolites and new biocatalysts.
摘要
土壤栖居放线菌菌株亚种是抗病毒抗生素基斯塔霉素A和B的产生菌。基因组测序和生物信息学分析揭示了负责这些非核糖体肽形成的基斯塔霉素生物合成基因簇的存在，以及大量尚未表征的生物合成途径。这包括聚酮化合物、核糖体和非核糖体肽，以及大量编码未知天然产物的萜类生物合成基因座。因此，该菌株的基因组数据是挖掘新型功能代谢物和新型生物催化剂的基因组宝库。
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