电子烟烟液口味对尼古丁摄入量及电子烟药理学的影响。
Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes.
作者信息
St Helen Gideon, Dempsey Delia A, Havel Christopher M, Jacob Peyton, Benowitz Neal L
机构信息
Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, CA, USA; Center for Tobacco Control Research and Education, University of California, San Francisco, CA, USA; Tobacco Center of Regulatory Science (TCORS), University of California, San Francisco, CA, USA.
Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, CA, USA.
出版信息
Drug Alcohol Depend. 2017 Sep 1;178:391-398. doi: 10.1016/j.drugalcdep.2017.05.042. Epub 2017 Jun 30.
OBJECTIVES
To describe the effect of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes.
METHODS
11 males and 3 females participated in a 3-day inpatient crossover study with strawberry, tobacco, and their usual flavor e-liquid. Nicotine levels were nominally 18mg/mL in the strawberry (pH 8.29) and tobacco (pH 9.10) e-liquids and ranged between 3-18mg/mL in the usual brands (mean pH 6.80). Each day consisted of a 15-puff session followed by 4h of abstinence, then 90min of ad libitum use. Subjects used a KangerTech mini ProTank 3.
RESULTS
After 15 puffs, the amount of nicotine inhaled and systemically retained were not significantly different between the strawberry and tobacco e-liquids but plasma AUC was significantly higher with the strawberry e-liquid. While not significantly different, C was 22% higher and various early time point AUCs to measure rate of rise of nicotine in blood ranged between 17 and 23% higher with the strawberry e-liquid compared to the tobacco e-liquid. During ad libitum use, systemic exposure to nicotine (AUC) was the same for the tobacco and usual brand e-liquids but were both significantly lower than after using the strawberry e-liquid. The usual flavors were more liked and satisfying than the strawberry and tobacco e-liquids.
CONCLUSION
Flavors influence nicotine exposure through flavor liking, may affect rate of nicotine absorption possibly through pH effects, and contribute to heart rate acceleration and subjective effects of e-cigarettes. E-cigarette users titrate their nicotine exposure but the extent of titration may vary across flavors.
目的
描述电子烟烟液口味对尼古丁摄入量及电子烟药理学的影响。
方法
11名男性和3名女性参与了一项为期3天的住院交叉研究，使用草莓味、烟草味以及他们常用口味的电子烟烟液。草莓味（pH 8.29）和烟草味（pH 9.10）电子烟烟液中的尼古丁含量标称均为18mg/mL，常用品牌烟液中的尼古丁含量在3 - 18mg/mL之间（平均pH 6.80）。每天包括一次15口的抽吸，随后禁欲4小时，然后自由使用90分钟。受试者使用康尔泰克迷你ProTank 3电子烟。
结果
抽吸15口后，草莓味和烟草味电子烟烟液吸入和全身留存的尼古丁量无显著差异，但草莓味电子烟烟液的血浆药时曲线下面积（AUC）显著更高。虽然差异不显著，但草莓味电子烟烟液的C值高22%，用于测量血液中尼古丁上升速率的各个早期时间点的AUC比烟草味电子烟烟液高17%至23%。在自由使用期间，烟草味和常用品牌电子烟烟液的尼古丁全身暴露量（AUC）相同，但均显著低于使用草莓味电子烟烟液后的暴露量。常用口味比草莓味和烟草味电子烟烟液更受欢迎且更令人满意。
结论
口味通过对口味的喜好影响尼古丁暴露，可能通过pH值效应影响尼古丁吸收速率，并导致心率加快和电子烟的主观效应。电子烟使用者会调整他们的尼古丁暴露量，但调整程度可能因口味而异。
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