Jackson Asti, Green Barry, Erythropel Hanno C, Kong Grace, Cavallo Dana A, Eid Tore, Gueorguieva Ralitza, Buta Eugenia, O'Malley Stephanie S, Krishnan-Sarin Suchitra
Department of Psychiatry.
Department of Surgery.
Exp Clin Psychopharmacol. 2021 Aug;29(4):355-365. doi: 10.1037/pha0000368. Epub 2020 Apr 16.
E-cigarettes are popular among adolescents. Given that flavors enhance e-cigarette appeal, this study examined the influence of flavors on nicotine in e-cigarettes. Youth e-cigarette users (average 26.2 days [SD = 3.6] in past 28 days) were randomized to use e-cigarettes containing 6 or 12 mg/mL of freebase nicotine and completed 4 test sessions. During the first 3 test sessions, participants completed 3 fixed puffing bouts (1 puffing bout = 10 puffs, 3 s each, 30-s interval), using menthol, green-apple, and unflavored e-liquids (50 propylene glycol [PG]/50 vegetable glycerin [VG]) with their assigned nicotine concentration in a random order using a ∼5.5-W V2 e-cigarette device. After each puffing bout, participants assessed subjective effects of nicotine and flavor. In the 4th test session, participants used any of the e-liquids they had tried in the earlier sessions, ad libitum for 60 min and the amount of e-liquid used for each flavor and the number of puffs was assessed. Participants (n = 49; 6 mg/mL [n = 24]; 12 mg/mL [n = 25]) were 63.3% male, 65.3% non-Hispanic White with an average age of 18.7 (SD = 0.9). Mixed models analysis revealed that green apple and 6 mg/mL of nicotine independently increased liking of e-cigarette taste. In addition, green apple produced higher ratings of fruitiness, sourness, sweetness, and menthol produced higher ratings of coolness. We did not observe any interactions between nicotine and flavor. Youth liked the taste of e-liquids containing green-apple flavor or low nicotine concentration which highlights the appeal of fruit flavors in e-cigarettes to adolescents. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
电子烟在青少年中很受欢迎。鉴于口味会增强电子烟的吸引力，本研究考察了口味对电子烟中尼古丁的影响。青少年电子烟使用者（过去28天内平均使用26.2天[标准差=3.6]）被随机分配使用含有6或12毫克/毫升游离碱尼古丁的电子烟，并完成4次测试环节。在前3次测试环节中，参与者使用薄荷醇、青苹果和无味电子烟液（50%丙二醇[PG]/50%蔬菜甘油[VG]），以随机顺序，使用约5.5瓦的V2电子烟设备，进行3次固定 puffing 回合（1个 puffing 回合=10次 puff，每次3秒，间隔30秒），尼古丁浓度为其分配的浓度。每次 puffing 回合后，参与者评估尼古丁和口味的主观效果。在第4次测试环节中，参与者随意使用他们在之前环节中尝试过的任何一种电子烟液，持续60分钟，并评估每种口味使用的电子烟液量和 puff 次数。参与者（n = 49；6毫克/毫升[n = 24]；12毫克/毫升[n = 25]）中63.3%为男性，65.3%为非西班牙裔白人，平均年龄18.7岁（标准差 = 0.9）。混合模型分析显示，青苹果味和6毫克/毫升尼古丁独立增加了对电子烟味道的喜爱。此外，青苹果味的果香、酸味、甜味评分更高，薄荷醇味的清凉感评分更高。我们没有观察到尼古丁和口味之间的任何相互作用。青少年喜欢含有青苹果味或低尼古丁浓度的电子烟液的味道，这凸显了电子烟中的水果口味对青少年的吸引力。（PsycInfo数据库记录（c）2021美国心理学会，保留所有权利）
