Vasu Samhita, Zhou Justin, Chen Jeffrey, Johnston Peter V, Kim Deok-Ho
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Korean Circ J. 2021 Dec;51(12):943-960. doi: 10.4070/kcj.2021.0291.
The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as that involve bioactive molecules. However, delivery remains one of the major challenges impeding such therapies from having clinical impact. Recent advancements in biomaterials-based approaches for cardiac regeneration have shown promise in clinical trials and animal studies in improving cardiac function, promoting angiogenesis, and reducing adverse immune response. This review will focus on current clinical studies of three contemporary biomaterials-based approaches for cardiac regeneration (extracellular vesicles, injectable hydrogels, and cardiac patches), remaining challenges and shortcomings to be overcome, and future directions for the use of biomaterials to promote cardiac regeneration.
心肌细胞增殖能力有限是心血管疾病死亡率和发病率的主要原因。目前存在基于细胞以及涉及生物活性分子的心脏再生疗法。然而，递送仍然是阻碍这些疗法产生临床影响的主要挑战之一。基于生物材料的心脏再生方法的最新进展在临床试验和动物研究中已显示出改善心脏功能、促进血管生成和减少不良免疫反应的前景。本综述将聚焦于三种当代基于生物材料的心脏再生方法（细胞外囊泡、可注射水凝胶和心脏补片）的当前临床研究、有待克服的挑战和缺点，以及使用生物材料促进心脏再生的未来方向。
