Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Department of Environmental Chemistry, Jordi Girona, 18, 08034 Barcelona, Catalonia, Spain.
UiT The Arctic University of Norway, Hansine Hansens veg, 18, 9019 Tromsø, Norway.
Environ Res. 2017 Oct;158:759-767. doi: 10.1016/j.envres.2017.07.033. Epub 2017 Jul 25.
The occurrence of organohalogen compounds in venous serum from post-partum mothers from two Argentinian cities, Salta and Ushuaia, has been investigated (n = 698). 4,4'-DDE was the most abundant compound in these cities, with geometric means of 33 and 67ng/g lipid weight, respectively. City of residence, age and parity were the main determinants of the accumulation of these compounds. Hexachlorobenzene (HCB) was the second most abundant pollutant in Ushuaia, 8.7ng/g lipid, and β-hexachlorocyclohexane (β-HCH) in Salta, 7.8ng/g lipid. Decabromodiphenyl ether was higher in Ushuaia than Salta, 8.2 and 4.1ng/g lipid, respectively. The predominance of β-HCH, 4,4'-DDE and 4,4'-DDT in Salta was related with higher use of pesticides for agricultural applications. The observed higher concentrations of 4,4'-DDE and 4,4'-DDT in the mothers from rural+semi-urban sites than in urban areas were consistent with this agricultural origin. In addition, the most volatile organochlorine compounds included in this study, HCB and α-HCH, were mainly found in Ushuaia. The concentrations of the studied organohalogen pollutants in Argentina were lower than those found in other similar studies which is consistent with the location of these cities in the southern hemisphere. Age, mainly for 4,4'-DDE and polychlorobiphenyl (PCB) congeners 138, 153 and 180, and parity, mainly for HCB, β-HCH, 4,4'-DDT and PCB congener 118, were the second main determinants of the concentrations of these compounds. Gestational weight gain also influenced on the maternal levels of HCB, β-HCH, 4,4'-DDT and PCB congeners 118, 138 and 153. Higher weight accumulation during pregnancy involved dilution of these persistent pollutants. Body mass index (BMI) was a statistically significant determinant for 4,4'-DDT, α-HCH and PCB congeners 153 and 180. The observed direct correspondence between higher BMI and 4,4'-DDT concentrations was in agreement with the above reported inputs related with agricultural applications. The reverse correspondence of BMI with α-HCH and the PCB congeners indicated higher dilution at higher weight increase.
已经调查了来自阿根廷两个城市萨尔塔和乌斯怀亚的产后母亲静脉血清中的有机卤代化合物的发生情况（n=698）。在这些城市中，4,4'-DDE 是最丰富的化合物，其脂质重量的几何平均值分别为 33 和 67ng/g。居住城市、年龄和产次是这些化合物积累的主要决定因素。六氯苯（HCB）是乌斯怀亚的第二大污染物，为 8.7ng/g 脂质，β-六氯环己烷（β-HCH）在萨尔塔为 7.8ng/g 脂质。十溴二苯醚在乌斯怀亚的含量高于萨尔塔，分别为 8.2 和 4.1ng/g 脂质。萨尔塔中β-HCH、4,4'-DDE 和 4,4'-DDT 的优势与农业应用中更高的杀虫剂使用有关。在农村+半城市地区的母亲中观察到的 4,4'-DDE 和 4,4'-DDT 浓度高于城市地区，这与农业起源一致。此外，本研究中包括的最易挥发的有机氯化合物 HCB 和 α-HCH 主要存在于乌斯怀亚。在所研究的有机卤代污染物的浓度在阿根廷低于其他类似研究中发现的，这与这些城市在南半球的位置一致。年龄，主要是 4,4'-DDE 和多氯联苯（PCB）同系物 138、153 和 180，以及产次，主要是 HCB、β-HCH、4,4'-DDT 和 PCB 同系物 118，是这些化合物浓度的第二大主要决定因素。妊娠体重增加也会影响 HCB、β-HCH、4,4'-DDT 和 PCB 同系物 118、138 和 153 的母体水平。怀孕期间体重的增加会导致这些持久性污染物的稀释。体重指数（BMI）是 4,4'-DDT、α-HCH 和 PCB 同系物 153 和 180 的统计学上显著决定因素。观察到的较高 BMI 与 4,4'-DDT 浓度之间的直接对应关系与上述报告的与农业应用相关的输入一致。BMI 与 α-HCH 和 PCB 同系物的反向对应关系表明，随着体重增加，稀释度更高。
