Hansen Solrunn, Nieboer Evert, Bravo Natalia, Økland Inger, Matiocevich Silvinia, Alvarez Marisa Viviana, Nilsen Stein Tore, Grimalt Joan O, Odland Jon Øyvind
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Box 6050 Langnes, NO-9037 Tromsø, Norway.
Environ Sci Process Impacts. 2017 Dec 13;19(12):1542-1553. doi: 10.1039/c7em00278e.
The EMASAR study is the first study to describe the body burden of OCs in Argentinian women after delivery. In total, 698 maternal serum samples from Salta (n = 498) and Ushuaia (n = 200) were collected in 2011-2012 and analyzed for a total of 7 polychlorinated biphenyls (PCBs) and 12 pesticide-related compounds. Only 11 of the compounds had detection rates above 60% in one or both places. Compared with Ushuaian women, those from Salta exhibited higher lipid-adjusted concentrations of p,p'-DDE, p,p'-DDT, β-HCH, and PCB 118 (p ≤ 0.003), with no differences in concentrations of PCB 153 and 138. After controlling for age, parity and heritage (born in the province or migrated there from other regions of Argentina), concentrations of p,p'-DDE, p,p'-DDT, β-HCH and all PCBs were significantly higher in Salta natives compared with Ushuaia natives or migrants (p ≤ 0.010). No variations between native and migrated Ushuaian women were observed other than for PCB 153 (6.1 versus 8.6 μg kg lipid, p = 0.022). Age was generally associated positively with the body burden of nearly all OCs and parity negatively so, with p,p'-DDD, o,p'-DDT, and o,p'-DDD residues and α-HCH in Ushuaia being the exceptions. The regional differences in OC concentrations are explained by contrasting domestic sources, historical and current uses, industrial emissions, dietary patterns and lifestyle factors, as well as long-range-transport. The relatively high PCB 118/PCB 180 ratio observed for both Argentinian communities likely reflects the use of technical mixtures with congener-specific composition. In a comprehensive comparison with other countries, the Argentinian OC concentrations were mostly in the lower range. It is concluded that a latitude effect equivalent to that operative in the Arctic region seems unlikely.
EMASAR研究是第一项描述阿根廷女性产后体内有机氯化合物（OCs）负荷情况的研究。2011年至2012年期间，共收集了来自萨尔塔（n = 498）和乌斯怀亚（n = 200）的698份孕妇血清样本，对总共7种多氯联苯（PCBs）和12种与农药相关的化合物进行了分析。在这两个地方中的一个或两个地方，只有11种化合物的检出率高于60%。与乌斯怀亚的女性相比，萨尔塔的女性体内p,p'-滴滴伊、p,p'-滴滴涕、β-六氯环己烷和多氯联苯118的脂质调整浓度更高（p≤0.003），而多氯联苯153和138的浓度没有差异。在控制了年龄、胎次和祖籍（出生在该省或从阿根廷其他地区迁移到该省）后，与乌斯怀亚的本地人或移民相比，萨尔塔本地人的p,p'-滴滴伊、p,p'-滴滴涕、β-六氯环己烷和所有多氯联苯的浓度显著更高（p≤0.010）。除了多氯联苯153外，未观察到乌斯怀亚本地女性和移民女性之间的差异（6.1对8.6μg/kg脂质，p = 0.022）。年龄通常与几乎所有有机氯化合物的体内负荷呈正相关，胎次则呈负相关，乌斯怀亚的p,p'-滴滴滴、o,p'-滴滴涕和o,p'-滴滴滴残留物以及α-六氯环己烷是例外。有机氯化合物浓度的区域差异可以通过国内来源、历史和当前用途、工业排放、饮食模式和生活方式因素以及长距离传输的差异来解释。在两个阿根廷社区中观察到的相对较高的多氯联苯118/多氯联苯180比率可能反映了具有特定同系物组成的工业混合物的使用情况。在与其他国家的全面比较中，阿根廷的有机氯化合物浓度大多处于较低水平。得出的结论是，类似于北极地区的纬度效应似乎不太可能存在。
