Department of Developmental Biology and Invertebrate Morphology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Krakow, Poland.
The Houston Methodist Research Institute and The Houston Methodist Hospital, 6670 Bertner Ave, Houston, TX, 77030, USA.
J Assist Reprod Genet. 2017 Nov;34(11):1405-1412. doi: 10.1007/s10815-017-1006-3. Epub 2017 Jul 28.
Early oocytes of nearly all animal species contain a transient organelle assemblage termed the Balbiani body. Structure and composition of this assemblage may vary even between closely related species. Despite this variability, the Balbiani body always comprises of numerous tightly clustered mitochondria and accumulations of nuage material. It has been suggested that the Balbiani body is an evolutionarily ancestral structure, which plays a role in various processes such as the localization of organelles and macromolecules to the germ plasm, lipidogenesis, as well as the selection/elimination of dysfunctional mitochondria from female germline cells. We suggest that the selection/elimination of mitochondria is a primary and evolutionarily ancestral function of Balbiani body, and that the other functions are secondary, evolutionarily derived additions. We propose a simple model explaining the role of the Balbiani body in the selection of mitochondria, i.e., in the mitochondrial DNA (mtDNA) bottleneck phenomenon.
几乎所有动物物种的早期卵母细胞都含有一种称为巴尔比尼体的瞬时细胞器集合体。即使在密切相关的物种之间，这种集合体的结构和组成也可能存在差异。尽管存在这种可变性，但巴尔比尼体始终由许多紧密聚集的线粒体和 nuage 物质的积累组成。有人认为巴尔比尼体是一种进化上的祖先结构，它在细胞器和大分子向生殖质的定位、脂类生成以及雌性生殖细胞中线粒体的功能障碍的选择/消除等各种过程中发挥作用。我们认为，线粒体的选择/消除是巴尔比尼体的主要和进化上的祖先功能，而其他功能是次要的、进化上衍生的附加功能。我们提出了一个简单的模型来解释巴尔比尼体在选择线粒体中的作用，即在线粒体 DNA（mtDNA）瓶颈现象中。
