Oe Mariko, Sakai Seigo, Yoshida Hideto, Okado Nao, Kaneda Haruna, Masuda Yasunobu, Urushibata Osamu
R&D Division, Kewpie Corporation, Sengawa-cho, Chofu-shi.
Department of Dermatology, Toho University Ohashi Medical Center, Ohashi, Meguro-ku, Tokyo, Japan.
Clin Cosmet Investig Dermatol. 2017 Jul 18;10:267-273. doi: 10.2147/CCID.S141845. eCollection 2017.
Hyaluronan (HA) has critical moisturizing property and high water retention capacity especially for human skin. This study aimed to evaluate the effect of oral intake of HA.
The mean molecular weight (MW) of HA is 2 k and 300 k. Sixty Japanese male and female subjects aged 22-59 years who presented with crow's feet wrinkles were randomly assigned to the HA 2 k or HA 300 k at 120 mg/day or the placebo group. The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks. The skin wrinkles were evaluated by image analysis of skin wrinkle replicas, and their skin condition was evaluated using a questionnaire survey.
During the study period, the HA groups showed better level of the whole sulcus volume ratio, wrinkle area ratio, and wrinkle volume ratio than the placebo group. After 8 weeks of ingestion, the HA 300 k group showed significantly diminished wrinkles compared with the placebo group. Skin luster and suppleness significantly improved after 12 weeks in all groups compared with the baseline.
The results suggest that oral HA (both HA 2 k and HA 300 k) inhibits skin wrinkles and improves skin condition.
透明质酸（HA）具有关键的保湿特性和高保水能力，对人体皮肤尤为重要。本研究旨在评估口服HA的效果。
HA的平均分子量（MW）为2k和300k。60名年龄在22 - 59岁、有鱼尾纹的日本男性和女性受试者被随机分配至每日服用120mg的2k HA组、300k HA组或安慰剂组。受试者以每日120mg的剂量服用HA或安慰剂，为期12周。通过对皮肤皱纹复制品的图像分析评估皮肤皱纹，并使用问卷调查评估他们的皮肤状况。
在研究期间，HA组在整个沟纹体积比、皱纹面积比和皱纹体积比方面均表现优于安慰剂组。摄入8周后，300k HA组与安慰剂组相比，皱纹明显减少。与基线相比，所有组在12周后皮肤光泽和柔软度均有显著改善。
结果表明，口服HA（2k HA和300k HA）均可抑制皮肤皱纹并改善皮肤状况。
