Department of Biomedical Engineering, Stony Brook University , Stony Brook, New York.
Tissue Eng Part A. 2018 Apr;24(7-8):641-652. doi: 10.1089/ten.TEA.2017.0117. Epub 2017 Sep 25.
This study investigates the effect of incorporation of one- or two-dimensional nanoparticles with distinct composition and morphology on the bioactivity of biodegradable, biocompatible polymer matrices. 0.2 wt% multiwalled carbon nanotubes, multiwalled graphene nanoribbons, graphene oxide nanoplatelets (GONPs), molybdenum disulfide nanoplatelets (MSNPs), or tungsten disulfide nanotubes (WSNTs) were uniformly dispersed in poly(lactic-co-glycolic acid) (PLGA) polymer. PLGA or nanoparticle-incorporated PLGA were then incubated with simulated body fluid (SBF) under physiological conditions for 1, 3, 7, or 14 days. Apatite collection on control and incorporated scaffolds was assessed. All groups showed apatite precipitate on the surface after 1 day of SBF incubation. After 14 days of SBF incubation, scaffolds incorporated with GONPs, MSNPs, or WSNTs showed significantly higher phosphate accumulation compared to PLGA scaffolds. Scaffolds incorporated with GONPs, MSNPs, or WSNTs should be studied in vivo to further investigate potential bioactivity, leading to enhanced integration and tissue repair at the bone-implant interface.
本研究考察了将具有不同组成和形态的一维或二维纳米粒子掺入可生物降解、生物相容的聚合物基质中对其生物活性的影响。0.2wt%的多壁碳纳米管、多壁石墨烯纳米带、氧化石墨烯纳米片（GONPs）、二硫化钼纳米片（MSNPs）或二硫化钨纳米管（WSNTs）均匀分散在聚（乳酸-共-乙醇酸）（PLGA）聚合物中。然后，将 PLGA 或掺入纳米粒子的 PLGA 在生理条件下与模拟体液（SBF）孵育 1、3、7 或 14 天。评估对照和掺入支架上的磷灰石收集情况。所有组在 SBF 孵育 1 天后均在表面上显示出磷灰石沉淀物。在 SBF 孵育 14 天后，掺入 GONPs、MSNPs 或 WSNTs 的支架与 PLGA 支架相比，磷酸盐积累明显增加。应在体内研究掺入 GONPs、MSNPs 或 WSNTs 的支架，以进一步研究潜在的生物活性，从而增强骨-植入物界面的整合和组织修复。
