Peterle Lucia, Sanfilippo Serena, Borgia Francesco, Li Pomi Federica, Vadalà Rossella, Costa Rosaria, Cicero Nicola, Gangemi Sebastiano
School and Operative Unit of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy.
School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy.
Foods. 2023 Jul 7;12(13):2629. doi: 10.3390/foods12132629.
Skin cancer is a prevalent type of cancer worldwide and has a high growth rate compared to other diseases. Although modern targeted therapies have improved the management of cutaneous neoplasms, there is an urgent requirement for a safer, more affordable, and effective chemoprevention and treatment strategy for skin cancer. Nutraceuticals, which are natural substances derived from food, have emerged as a potential alternative or adjunctive treatment option. In this review, we explore the current evidence on the use of omega-3 fatty acids and polyphenols (curcumin, epigallocatechin gallate, apigenin, resveratrol, and genistein) for the treatment of melanoma and non-melanoma skin cancer (NMSC), as well as in their prevention. We discuss the mechanisms of action of the aforementioned nutraceuticals and their probable therapeutic benefits in skin cancer. Omega-3 fatty acids, curcumin, epigallocatechin gallate, apigenin, resveratrol, and genistein have several properties, among which are anti-inflammatory and anti-tumor, which can help to prevent and treat skin cancer. However, their effectiveness is limited due to poor bioavailability. Nanoparticles and other delivery systems can improve their absorption and targeting. More research is needed to evaluate their safety and effectiveness as a natural approach to skin cancer prevention and treatment. These compounds should not replace conventional cancer treatments, but may be used as complementary therapy under the guidance of a healthcare professional.
皮肤癌是全球一种常见的癌症类型，与其他疾病相比具有较高的增长率。尽管现代靶向治疗已改善了皮肤肿瘤的管理，但迫切需要一种更安全、更经济且有效的皮肤癌化学预防和治疗策略。营养保健品是从食物中提取的天然物质，已成为一种潜在的替代或辅助治疗选择。在本综述中，我们探讨了关于使用ω-3脂肪酸和多酚（姜黄素、表没食子儿没食子酸酯、芹菜素、白藜芦醇和染料木黄酮）治疗黑色素瘤和非黑色素瘤皮肤癌（NMSC）及其预防的现有证据。我们讨论了上述营养保健品的作用机制及其在皮肤癌中可能的治疗益处。ω-3脂肪酸、姜黄素、表没食子儿没食子酸酯、芹菜素、白藜芦醇和染料木黄酮具有多种特性，其中包括抗炎和抗肿瘤特性，这有助于预防和治疗皮肤癌。然而，由于生物利用度差，它们的有效性受到限制。纳米颗粒和其他递送系统可以提高它们的吸收和靶向性。需要更多研究来评估它们作为皮肤癌预防和治疗的天然方法的安全性和有效性。这些化合物不应取代传统的癌症治疗方法，但在医疗保健专业人员的指导下可作为辅助疗法使用。
