用于新型生物墨水开发的挤出式生物打印分辨率的数学模型
A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks.
作者信息
Suntornnond Ratima, Tan Edgar Yong Sheng, An Jia, Chua Chee Kai
机构信息
Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798.
出版信息
Materials (Basel). 2016 Sep 6;9(9):756. doi: 10.3390/ma9090756.
Abstract
Pneumatic extrusion-based bioprinting is a recent and interesting technology that is very useful for biomedical applications. However, many process parameters in the bioprinter need to be fully understood in order to print at an adequate resolution. In this paper, a simple yet accurate mathematical model to predict the printed width of a continuous hydrogel line is proposed, in which the resolution is expressed as a function of nozzle size, pressure, and printing speed. A thermo-responsive hydrogel, pluronic F127, is used to validate the model predictions. This model could provide a platform for future correlation studies on pneumatic extrusion-based bioprinting as well as for developing new bioink formulations.
摘要
基于气动挤压的生物打印是一项新兴且有趣的技术，在生物医学应用中非常有用。然而，为了以足够的分辨率进行打印，生物打印机中的许多工艺参数需要被充分理解。本文提出了一个简单而准确的数学模型来预测连续水凝胶线的打印宽度，其中分辨率表示为喷嘴尺寸、压力和打印速度的函数。使用一种热响应性水凝胶——普朗尼克F127来验证模型预测。该模型可为未来基于气动挤压的生物打印相关研究以及开发新的生物墨水配方提供一个平台。
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