Section on Functional Imaging Methods, NIMH, NIH, Bethesda, MD, USA.
Section on Functional Imaging Methods, NIMH, NIH, Bethesda, MD, USA; Functional MRI Core, NIH, Bethesda, MD, USA.
Neuroimage. 2018 Oct 15;180(Pt B):526-533. doi: 10.1016/j.neuroimage.2017.08.006. Epub 2017 Aug 3.
The temporal evolution of functional connectivity (FC) within the confines of individual scans is nowadays often explored with functional neuroimaging. This is particularly true for resting-state; yet, FC-dynamics have also been investigated as subjects engage on numerous tasks. It is these research efforts that constitute the core of this survey. First, empirical observations on how FC differs between task and rest-independent of temporal scale-are reviewed, as they underscore how, despite overall preservation of network topography, the brain's FC does reconfigure in systematic ways to accommodate task demands. Next, reports on the relationships between instantaneous FC and perception/performance in subsequent trials are discussed. Similarly, research where different aspects of task-concurrent FC-dynamics are explored or utilized to predict ongoing mental states are also examined. The manuscript finishes with an incomplete list of challenges that hopefully fuels future work in this vibrant area of neuroscientific research. Overall, this review concludes that task-concurrent FC-dynamics, when properly characterized, are relevant to behavior, and that their translational value holds considerable promise.
如今，在个体扫描范围内，功能连接（FC）的时间演变通常通过功能神经影像学进行探索。这在静息状态下尤其如此；然而，当受试者参与众多任务时，FC 动态也已被研究。这些研究工作构成了本调查的核心。首先，我们回顾了关于任务和休息之间的 FC 差异的经验观察（独立于时间尺度），因为这些观察强调了尽管网络拓扑总体上保持不变，但大脑的 FC 确实以系统的方式重新配置以适应任务需求。接下来，讨论了瞬时 FC 与后续试验中感知/表现之间的关系报告。同样，还研究了探索任务并发 FC 动态的不同方面或利用其来预测正在进行的心理状态的研究。本文以一个不完整的挑战列表结束，希望为这个充满活力的神经科学研究领域的未来工作提供动力。总的来说，本综述得出结论，任务并发 FC 动态在适当表征时与行为相关，并且它们的转化价值具有很大的潜力。
